Expression of BIK in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

BCL2-interacting killer (apoptosis-inducing)

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA051360

GENE INFORMATION
Gene name	BIK (HGNC Symbol)
Synonyms	NBK
Description	BCL2-interacting killer (apoptosis-inducing) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene shares a critical BH3 domain with other death-promoting proteins, such as BID, BAK, BAD and BAX, that is required for its pro-apoptotic activity, and for interaction with anti-apoptotic members of the BCL2 family, and viral survival-promoting proteins. Since the activity of this protein is suppressed in the presence of survival-promoting proteins, it is suggested as a likely target for anti-apoptotic proteins. [provided by RefSeq, Sep 2011]
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	43110748 - 43129712
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100290 (version 83.38)
Entrez gene	638
UniProt	Q13323 (UniProt - Evidence at protein level)
neXtProt	NX_Q13323
Antibodypedia	BIK antibodies

PROTEIN BROWSER

BIK-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BIK-001 ENSP00000216115 ENST00000216115	Q13323 [Direct mapping] Bcl-2-interacting killer A0A024R4X6 [Target identity:100%; Query identity:100%] BCL2-interacting killer (Apoptosis-inducing), isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005740 [mitochondrial envelope] GO:0006915 [apoptotic process] GO:0007283 [spermatogenesis] GO:0008584 [male gonad development] GO:0008637 [apoptotic mitochondrial changes] GO:0012505 [endomembrane system] GO:0016021 [integral component of membrane] GO:0031966 [mitochondrial membrane] GO:0032464 [positive regulation of protein homooligomerization] GO:0042981 [regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051400 [BH domain binding] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] Show all	160 aa 18 kDa	No	1