Expression of MCAT in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Malonyl CoA:ACP acyltransferase (mitochondrial)

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035471

GENE INFORMATION
Gene name	MCAT (HGNC Symbol)
Synonyms	fabD, FASN2C, MCT, MT, NET62
Description	Malonyl CoA:ACP acyltransferase (mitochondrial) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	43132206 - 43143394
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100294 (version 83.38)
Entrez gene	27349
UniProt	Q8IVS2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVS2
Antibodypedia	MCAT antibodies

PROTEIN BROWSER

MCAT-001	MCAT-002	MCAT-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MCAT-001 ENSP00000290429 ENST00000290429	Q8IVS2 [Direct mapping] Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004314 [[acyl-carrier-protein] S-malonyltransferase activity] GO:0005739 [mitochondrion] GO:0006633 [fatty acid biosynthetic process] GO:0008152 [metabolic process] GO:0016740 [transferase activity] GO:0044822 [poly(A) RNA binding] Show all	390 aa 43 kDa	No	0
MCAT-002 ENSP00000331306 ENST00000327555	Q8IVS2 [Direct mapping] Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Show all	Enzymes ENZYME proteins Transferases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004314 [[acyl-carrier-protein] S-malonyltransferase activity] GO:0005739 [mitochondrion] GO:0006633 [fatty acid biosynthetic process] GO:0008152 [metabolic process] GO:0016740 [transferase activity] GO:0044822 [poly(A) RNA binding] Show all	180 aa 19.2 kDa	No	0
MCAT-004 ENSP00000477216 ENST00000608052	V9GYY6 [Direct mapping] Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016740 [transferase activity] Show all	87 aa 9 kDa	No	0