Cell atlas - ARSA - The Human Protein Atlas

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ARSA

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus

Human cell
	Cytosol
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	ARSA
Gene description	Arylsulfatase A
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (Karpas-707)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (uncertain)
Additional location	In addition localized to the Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA005554
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the cytosol.

Main location

Golgi apparatus (uncertain)

Additional location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA005554	U-2 OS	Golgi apparatus
	HPA005554	U-2 OS	Cytosol
	HPA005554	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	ARSA
Synonyms
Description	Arylsulfatase A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2010]
Chromosome	22
Cytoband	q13.33
Chromosome location (bp)	50622754 - 50628173
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100299 (version 83.38)
Entrez gene	410
UniProt	P15289 (UniProt - Evidence at protein level)
neXtProt	NX_P15289
Antibodypedia	ARSA antibodies

PROTEIN BROWSER

ARSA-001	ARSA-002	ARSA-003	ARSA-004	ARSA-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARSA-001 ENSP00000216124 ENST00000216124	A0A0C4DFZ2 [Direct mapping] Arylsulfatase A Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0003824 [catalytic activity] GO:0004065 [arylsulfatase activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0006914 [autophagy] GO:0007339 [binding of sperm to zona pellucida] GO:0007417 [central nervous system development] GO:0007584 [response to nutrient] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0009268 [response to pH] GO:0016021 [integral component of membrane] GO:0031232 [extrinsic component of external side of plasma membrane] GO:0043627 [response to estrogen] GO:0045471 [response to ethanol] GO:0051597 [response to methylmercury] Show all	509 aa 53.8 kDa	Yes	0
ARSA-002 ENSP00000412542 ENST00000453344	P15289 [Direct mapping] Arylsulfatase A Arylsulfatase A component B Arylsulfatase A component C Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004065 [arylsulfatase activity] GO:0004098 [cerebroside-sulfatase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0005788 [endoplasmic reticulum lumen] GO:0006665 [sphingolipid metabolic process] GO:0006687 [glycosphingolipid metabolic process] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] GO:0043202 [lysosomal lumen] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	423 aa 44.9 kDa	No	0
ARSA-003 ENSP00000378981 ENST00000395619	A0A0C4DFZ2 [Direct mapping] Arylsulfatase A Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] Show all	509 aa 53.8 kDa	Yes	0
ARSA-004 ENSP00000348406 ENST00000356098	A0A0C4DFZ2 [Direct mapping] Arylsulfatase A Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] Show all	509 aa 53.8 kDa	Yes	0
ARSA-005 ENSP00000378983 ENST00000395621	A0A0C4DFZ2 [Direct mapping] Arylsulfatase A Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] GO:0008484 [sulfuric ester hydrolase activity] Show all	509 aa 53.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.