Expression of ACO2 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Aconitase 2, mitochondrial

Protein class

Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA001097

GENE INFORMATION
Gene name	ACO2 (HGNC Symbol)
Synonyms	ACONM
Description	Aconitase 2, mitochondrial (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	41469125 - 41528989
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100412 (version 83.38)
Entrez gene	50
UniProt	Q99798 (UniProt - Evidence at protein level)
neXtProt	NX_Q99798
Antibodypedia	ACO2 antibodies

PROTEIN BROWSER

ACO2-001	ACO2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACO2-001 ENSP00000216254 ENST00000216254	Q99798 [Direct mapping] Aconitate hydratase, mitochondrial Show all	Enzymes ENZYME proteins Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003994 [aconitate hydratase activity] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006091 [generation of precursor metabolites and energy] GO:0006099 [tricarboxylic acid cycle] GO:0006101 [citrate metabolic process] GO:0006102 [isocitrate metabolic process] GO:0008152 [metabolic process] GO:0043209 [myelin sheath] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0051538 [3 iron, 4 sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] Show all	780 aa 85.4 kDa	No	0
ACO2-002 ENSP00000379769 ENST00000396512	A2A274 [Direct mapping] Aconitate hydratase, mitochondrial Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0008152 [metabolic process] Show all	805 aa 87.8 kDa	No	0