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PMM1

GENERAL INFORMATION

Gene name

 PMM1

Gene description

 Phosphomannomutase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Subcellular location is contradicted by limited external data.

Reliability score

 Uncertain based on 1 antibody.
HPA030712
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PMM1 (HGNC Symbol)

Synonyms

 Sec53

Description

 Phosphomannomutase 1 (HGNC Symbol)

Entrez gene summary

 Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol (GPI) anchored proteins. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q13.2

Chromosome location (bp)

 41576894 - 41589890

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100417 (version 83.38)

Entrez gene

 5372

UniProt

 Q92871 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92871

Antibodypedia

 PMM1 antibodies

PROTEIN BROWSER
PMM1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PMM1-001
ENSP00000216259
ENST00000216259
Q92871 [Direct mapping]
Phosphomannomutase 1
A0A024R1U5 [Target identity:100%; Query identity:100%]
Phosphomannomutase
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004615 [phosphomannomutase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006013 [mannose metabolic process]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0008152 [metabolic process]
GO:0009298 [GDP-mannose biosynthetic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043025 [neuronal cell body]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046872 [metal ion binding]
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 262 aa
29.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.