Cell atlas - BRD1 - The Human Protein Atlas

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BRD1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear speckles

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	BRD1
Gene description	Bromodomain containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear speckles (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA001063
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nuclear speckles.

Main location

Nuclear speckles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001063	A-431	Nuclear speckles
	HPA001063	U-2 OS	Nuclear speckles
	HPA001063	U-251 MG	Nuclear speckles

GENE INFORMATION
Gene name	BRD1 (HGNC Symbol)
Synonyms	BRL, BRPF2
Description	Bromodomain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schozophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Chromosome	22
Cytoband	q13.33
Chromosome location (bp)	49773283 - 49827512
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100425 (version 83.38)
Entrez gene	23774
UniProt	O95696 (UniProt - Evidence at protein level)
neXtProt	NX_O95696
Antibodypedia	BRD1 antibodies

PROTEIN BROWSER

BRD1-001	BRD1-002	BRD1-003	BRD1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRD1-001 ENSP00000384076 ENST00000404034	O95696 [Direct mapping] Bromodomain-containing protein 1 A0A024R4W4 [Target identity:100%; Query identity:100%] Bromodomain containing 1, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0042393 [histone binding] GO:0043966 [histone H3 acetylation] GO:0070776 [MOZ/MORF histone acetyltransferase complex] Show all	1058 aa 119.5 kDa	No	0
BRD1-002 ENSP00000216267 ENST00000216267	O95696 [Direct mapping] Bromodomain-containing protein 1 A0A024R4W4 [Target identity:100%; Query identity:100%] Bromodomain containing 1, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0042393 [histone binding] GO:0043966 [histone H3 acetylation] GO:0070776 [MOZ/MORF histone acetyltransferase complex] Show all	1058 aa 119.5 kDa	No	0
BRD1-003 ENSP00000385858 ENST00000404760	O95696 [Direct mapping] Bromodomain-containing protein 1 A0A024R4V5 [Target identity:100%; Query identity:100%] Bromodomain containing 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0042393 [histone binding] GO:0043966 [histone H3 acetylation] GO:0070776 [MOZ/MORF histone acetyltransferase complex] Show all	1189 aa 133.2 kDa	No	0
BRD1-201 ENSP00000410042 ENST00000457780	O95696 [Direct mapping] Bromodomain-containing protein 1 A0A024R4V5 [Target identity:100%; Query identity:100%] Bromodomain containing 1, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0030425 [dendrite] GO:0035902 [response to immobilization stress] GO:0042393 [histone binding] GO:0043204 [perikaryon] GO:0043966 [histone H3 acetylation] GO:0051602 [response to electrical stimulus] GO:0070776 [MOZ/MORF histone acetyltransferase complex] Show all	1189 aa 133.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.