Expression of KCNK10 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, two pore domain subfamily K, member 10

Protein class

Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA030462

GENE INFORMATION
Gene name	KCNK10 (HGNC Symbol)
Synonyms	K2p10.1, PPP1R97, TREK-2, TREK2
Description	Potassium channel, two pore domain subfamily K, member 10 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]
Chromosome	14
Cytoband	q31.3
Chromosome location (bp)	88180103 - 88326907
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100433 (version 83.38)
Entrez gene	54207
UniProt	P57789 (UniProt - Evidence at protein level)
neXtProt	NX_P57789
Antibodypedia	KCNK10 antibodies

PROTEIN BROWSER

KCNK10-001	KCNK10-002	KCNK10-003	KCNK10-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNK10-001 ENSP00000343104 ENST00000340700	P57789 [Direct mapping] Potassium channel subfamily K member 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	538 aa 59.8 kDa	Yes	6
KCNK10-002 ENSP00000312811 ENST00000319231	P57789 [Direct mapping] Potassium channel subfamily K member 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0007613 [memory] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	543 aa 60.3 kDa	No	6
KCNK10-003 ENSP00000310568 ENST00000312350	P57789 [Direct mapping] Potassium channel subfamily K member 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005244 [voltage-gated ion channel activity] GO:0005267 [potassium channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0007165 [signal transduction] GO:0007268 [synaptic transmission] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0034765 [regulation of ion transmembrane transport] GO:0071805 [potassium ion transmembrane transport] Show all	543 aa 60.1 kDa	No	6
KCNK10-004 ENSP00000452587 ENST00000556282	G3V5Y5 [Direct mapping] Potassium channel subfamily K member 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005887 [integral component of plasma membrane] GO:0022841 [potassium ion leak channel activity] GO:0030322 [stabilization of membrane potential] GO:0071805 [potassium ion transmembrane transport] Show all	157 aa 16.5 kDa	No	1