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PRMT5

CANCER ATLAS

Gene description

 Protein arginine methyltransferase 5

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA005525
HPA064708
CAB012459

GENE INFORMATION

Gene name

 PRMT5 (HGNC Symbol)

Synonyms

 HRMT1L5, SKB1, SKB1Hs

Description

 Protein arginine methyltransferase 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 22920511 - 22929585

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100462 (version 83.38)

Entrez gene

 10419

UniProt

 O14744 (UniProt - Evidence at protein level)

neXtProt

 NX_O14744

Antibodypedia

 PRMT5 antibodies

PROTEIN BROWSER
«
PRMT5-003
PRMT5-004
PRMT5-006
PRMT5-007
PRMT5-008
PRMT5-010
PRMT5-014
PRMT5-015
PRMT5-017
PRMT5-018
PRMT5-020
PRMT5-021
PRMT5-022
PRMT5-026
PRMT5-027
PRMT5-028
PRMT5-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRMT5-003
ENSP00000319169
ENST00000324366
O14744 [Direct mapping]
Protein arginine N-methyltransferase 5 Protein arginine N-methyltransferase 5, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0007088 [regulation of mitotic nuclear division]
GO:0008168 [methyltransferase activity]
GO:0008283 [cell proliferation]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0010467 [gene expression]
GO:0016274 [protein-arginine N-methyltransferase activity]
GO:0018216 [peptidyl-arginine methylation]
GO:0019918 [peptidyl-arginine methylation, to symmetrical-dimethyl arginine]
GO:0032403 [protein complex binding]
GO:0032922 [circadian regulation of gene expression]
GO:0034660 [ncRNA metabolic process]
GO:0034709 [methylosome]
GO:0034969 [histone arginine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0035243 [protein-arginine omega-N symmetric methyltransferase activity]
GO:0035246 [peptidyl-arginine N-methylation]
GO:0042118 [endothelial cell activation]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043234 [protein complex]
GO:0043985 [histone H4-R3 methylation]
GO:0044030 [regulation of DNA methylation]
GO:0045596 [negative regulation of cell differentiation]
GO:0046982 [protein heterodimerization activity]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0090161 [Golgi ribbon formation]
GO:0097421 [liver regeneration]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 637 aa
72.7 kDa 		No 0
PRMT5-004
ENSP00000380582
ENST00000397440
O14744 [Direct mapping]
Protein arginine N-methyltransferase 5 Protein arginine N-methyltransferase 5, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0007088 [regulation of mitotic nuclear division]
GO:0008168 [methyltransferase activity]
GO:0008283 [cell proliferation]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0010467 [gene expression]
GO:0016274 [protein-arginine N-methyltransferase activity]
GO:0018216 [peptidyl-arginine methylation]
GO:0019918 [peptidyl-arginine methylation, to symmetrical-dimethyl arginine]
GO:0032922 [circadian regulation of gene expression]
GO:0034660 [ncRNA metabolic process]
GO:0034709 [methylosome]
GO:0034969 [histone arginine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0035243 [protein-arginine omega-N symmetric methyltransferase activity]
GO:0035246 [peptidyl-arginine N-methylation]
GO:0042118 [endothelial cell activation]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043985 [histone H4-R3 methylation]
GO:0046982 [protein heterodimerization activity]
GO:0090161 [Golgi ribbon formation]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 466 aa
53.6 kDa 		No 0
PRMT5-006
ENSP00000452501
ENST00000557443
H0YJY6 [Direct mapping]
Protein arginine N-methyltransferase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0034969 [histone arginine methylation]
GO:0035246 [peptidyl-arginine N-methylation]
Show all
 61 aa
6.9 kDa 		No 0
PRMT5-007
ENSP00000380583
ENST00000397441
O14744 [Direct mapping]
Protein arginine N-methyltransferase 5 Protein arginine N-methyltransferase 5, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0007088 [regulation of mitotic nuclear division]
GO:0008168 [methyltransferase activity]
GO:0008283 [cell proliferation]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0010467 [gene expression]
GO:0016274 [protein-arginine N-methyltransferase activity]
GO:0018216 [peptidyl-arginine methylation]
GO:0019918 [peptidyl-arginine methylation, to symmetrical-dimethyl arginine]
GO:0032922 [circadian regulation of gene expression]
GO:0034660 [ncRNA metabolic process]
GO:0034709 [methylosome]
GO:0034969 [histone arginine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0035243 [protein-arginine omega-N symmetric methyltransferase activity]
GO:0035246 [peptidyl-arginine N-methylation]
GO:0042118 [endothelial cell activation]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043985 [histone H4-R3 methylation]
GO:0046982 [protein heterodimerization activity]
GO:0090161 [Golgi ribbon formation]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 620 aa
71.3 kDa 		No 0
PRMT5-008
ENSP00000216350
ENST00000216350
O14744 [Direct mapping]
Protein arginine N-methyltransferase 5 Protein arginine N-methyltransferase 5, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0007088 [regulation of mitotic nuclear division]
GO:0008168 [methyltransferase activity]
GO:0008283 [cell proliferation]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0010467 [gene expression]
GO:0016274 [protein-arginine N-methyltransferase activity]
GO:0018216 [peptidyl-arginine methylation]
GO:0019918 [peptidyl-arginine methylation, to symmetrical-dimethyl arginine]
GO:0032922 [circadian regulation of gene expression]
GO:0034660 [ncRNA metabolic process]
GO:0034709 [methylosome]
GO:0034969 [histone arginine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0035243 [protein-arginine omega-N symmetric methyltransferase activity]
GO:0035246 [peptidyl-arginine N-methylation]
GO:0042118 [endothelial cell activation]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043985 [histone H4-R3 methylation]
GO:0046982 [protein heterodimerization activity]
GO:0090161 [Golgi ribbon formation]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 576 aa
66.3 kDa 		No 0
PRMT5-010
ENSP00000452555
ENST00000553897
O14744 [Direct mapping]
Protein arginine N-methyltransferase 5 Protein arginine N-methyltransferase 5, N-terminally processed
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0007088 [regulation of mitotic nuclear division]
GO:0008168 [methyltransferase activity]
GO:0008283 [cell proliferation]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0010467 [gene expression]
GO:0016274 [protein-arginine N-methyltransferase activity]
GO:0018216 [peptidyl-arginine methylation]
GO:0019918 [peptidyl-arginine methylation, to symmetrical-dimethyl arginine]
GO:0032922 [circadian regulation of gene expression]
GO:0034660 [ncRNA metabolic process]
GO:0034709 [methylosome]
GO:0034969 [histone arginine methylation]
GO:0035097 [histone methyltransferase complex]
GO:0035243 [protein-arginine omega-N symmetric methyltransferase activity]
GO:0035246 [peptidyl-arginine N-methylation]
GO:0042118 [endothelial cell activation]
GO:0043021 [ribonucleoprotein complex binding]
GO:0043985 [histone H4-R3 methylation]
GO:0046982 [protein heterodimerization activity]
GO:0090161 [Golgi ribbon formation]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 593 aa
67.7 kDa 		No 0
PRMT5-014
ENSP00000450737
ENST00000553550
G3V2L6 [Direct mapping]
Protein arginine N-methyltransferase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0034969 [histone arginine methylation]
GO:0035246 [peptidyl-arginine N-methylation]
Show all
 183 aa
20.8 kDa 		No 0
PRMT5-015
ENSP00000452411
ENST00000554910
G3V5L5 [Direct mapping]
Protein arginine N-methyltransferase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0034969 [histone arginine methylation]
GO:0035246 [peptidyl-arginine N-methylation]
Show all
 170 aa
19.7 kDa 		No 0
PRMT5-017
ENSP00000450956
ENST00000553502
H0YJ77 [Direct mapping]
Protein arginine N-methyltransferase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0034969 [histone arginine methylation]
GO:0035246 [peptidyl-arginine N-methylation]
Show all
 138 aa
16.2 kDa 		No 0
PRMT5-018
ENSP00000452509
ENST00000556043
G3V5T6 [Direct mapping]
Protein arginine N-methyltransferase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0034969 [histone arginine methylation]
GO:0035246 [peptidyl-arginine N-methylation]
Show all
 104 aa
12.6 kDa 		No 0
PRMT5-020
ENSP00000452409
ENST00000555530
H0YJX6 [Direct mapping]
Protein arginine N-methyltransferase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0034969 [histone arginine methylation]
GO:0035246 [peptidyl-arginine N-methylation]
Show all
 279 aa
32.3 kDa 		No 0
PRMT5-021
ENSP00000451245
ENST00000555454
H0YJD3 [Direct mapping]
Protein arginine N-methyltransferase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0034969 [histone arginine methylation]
GO:0035246 [peptidyl-arginine N-methylation]
Show all
 177 aa
20.2 kDa 		No 0
PRMT5-022
ENSP00000387663
ENST00000454731
H7BZ44 [Direct mapping]
Protein arginine N-methyltransferase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0034969 [histone arginine methylation]
GO:0035246 [peptidyl-arginine N-methylation]
Show all
 179 aa
20.5 kDa 		No 0
PRMT5-026
ENSP00000409482
ENST00000421938
C9JSX3 [Direct mapping]
Protein arginine N-methyltransferase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0034969 [histone arginine methylation]
GO:0035246 [peptidyl-arginine N-methylation]
Show all
 186 aa
20.6 kDa 		No 0
PRMT5-027
ENSP00000450919
ENST00000556616
G3V2X6 [Direct mapping]
Protein arginine N-methyltransferase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0034969 [histone arginine methylation]
GO:0035246 [peptidyl-arginine N-methylation]
Show all
 185 aa
20.6 kDa 		No 0
PRMT5-028
ENSP00000452218
ENST00000554867
G3V580 [Direct mapping]
Protein arginine N-methyltransferase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006479 [protein methylation]
GO:0008168 [methyltransferase activity]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0034969 [histone arginine methylation]
GO:0035246 [peptidyl-arginine N-methylation]
Show all
 180 aa
20.4 kDa 		No 0
PRMT5-201
ENSP00000485787
ENST00000627278
G3V507 [Direct mapping]
Protein arginine N-methyltransferase 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008469 [histone-arginine N-methyltransferase activity]
GO:0034969 [histone arginine methylation]
Show all
 42 aa
4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.