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AP4S1

CANCER ATLAS

Gene description

 Adaptor-related protein complex 4, sigma 1 subunit

Protein class

 Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039963

GENE INFORMATION

Gene name

 AP4S1 (HGNC Symbol)

Synonyms

 AP47B, CLA20, SPG52

Description

 Adaptor-related protein complex 4, sigma 1 subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the adaptor complexes small subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is the small subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Mutations in this gene are associated with spastic quadriplegic cerebral palsy-6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Dec 2011]

Chromosome

 14

Cytoband

 q12

Chromosome location (bp)

 31025106 - 31096450

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100478 (version 83.38)

Entrez gene

 11154

UniProt

 Q9Y587 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9Y587

Antibodypedia

 AP4S1 antibodies

PROTEIN BROWSER
«
AP4S1-001
AP4S1-002
AP4S1-003
AP4S1-004
AP4S1-005
AP4S1-006
AP4S1-007
AP4S1-008
AP4S1-009
AP4S1-201
AP4S1-202
AP4S1-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP4S1-001
ENSP00000216366
ENST00000216366
Q9Y587 [Direct mapping]
AP-4 complex subunit sigma-1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005905 [coated pit]
GO:0006810 [transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0061024 [membrane organization]
Show all
 159 aa
18.6 kDa 		No 0
AP4S1-002
ENSP00000438170
ENST00000542754
Q9Y587 [Direct mapping]
AP-4 complex subunit sigma-1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005905 [coated pit]
GO:0006810 [transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0061024 [membrane organization]
Show all
 144 aa
17 kDa 		No 0
AP4S1-003
ENSP00000334484
ENST00000334725
Q9Y587 [Direct mapping]
AP-4 complex subunit sigma-1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005905 [coated pit]
GO:0006810 [transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0061024 [membrane organization]
Show all
 149 aa
17.4 kDa 		No 0
AP4S1-004
ENSP00000452383
ENST00000554609
G3V5J6 [Direct mapping]
AP-4 complex subunit sigma-1; Adaptor-related protein complex 4, sigma 1 subunit, isoform CRA_e
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016020 [membrane]
Show all
 102 aa
12.2 kDa 		No 0
AP4S1-005
ENSP00000450768
ENST00000554345
Q9Y587 [Direct mapping]
AP-4 complex subunit sigma-1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005905 [coated pit]
GO:0006810 [transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0061024 [membrane organization]
Show all
 135 aa
15.7 kDa 		No 0
AP4S1-006
ENSP00000451479
ENST00000557346
G3V3X7 [Direct mapping]
AP-4 complex subunit sigma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
Show all
 133 aa
15.8 kDa 		No 0
AP4S1-007
ENSP00000451918
ENST00000556232
G3V4P7 [Direct mapping]
AP-4 complex subunit sigma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
Show all
 98 aa
11.8 kDa 		No 0
AP4S1-008
ENSP00000451609
ENST00000555417
A0A0G2JL90 [Direct mapping]
AP-4 complex subunit sigma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 8 aa
1 kDa 		No 0
AP4S1-009
ENSP00000451614
ENST00000556480
H0YJI3 [Direct mapping]
AP-4 complex subunit sigma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
Show all
 83 aa
9.9 kDa 		No 0
AP4S1-201
ENSP00000322508
ENST00000313566
Q9Y587 [Direct mapping]
AP-4 complex subunit sigma-1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005905 [coated pit]
GO:0006810 [transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0061024 [membrane organization]
Show all
 149 aa
17.4 kDa 		No 0
AP4S1-202
ENSP00000477631
ENST00000616371
Q9Y587 [Direct mapping]
AP-4 complex subunit sigma-1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005905 [coated pit]
GO:0006810 [transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0061024 [membrane organization]
Show all
 144 aa
17 kDa 		No 0
AP4S1-203
ENSP00000482876
ENST00000622409
Q9Y587 [Direct mapping]
AP-4 complex subunit sigma-1
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005905 [coated pit]
GO:0006810 [transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0031904 [endosome lumen]
GO:0032588 [trans-Golgi network membrane]
GO:0061024 [membrane organization]
Show all
 144 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.