Expression of DAAM1 in cancer - Summary

CANCER ATLAS

Gene description

Dishevelled associated activator of morphogenesis 1

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026605

GENE INFORMATION
Gene name	DAAM1 (HGNC Symbol)
Synonyms	KIAA0666
Description	Dishevelled associated activator of morphogenesis 1 (HGNC Symbol)
Entrez gene summary	Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
Chromosome	14
Cytoband	q23.1
Chromosome location (bp)	59188646 - 59371405
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100592 (version 83.38)
Entrez gene	23002
UniProt	Q9Y4D1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y4D1
Antibodypedia	DAAM1 antibodies

PROTEIN BROWSER

DAAM1-001	DAAM1-007	DAAM1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DAAM1-001 ENSP00000378557 ENST00000395125	Q9Y4D1 [Direct mapping] Disheveled-associated activator of morphogenesis 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003779 [actin binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] GO:0042802 [identical protein binding] Show all	1078 aa 123.5 kDa	No	0
DAAM1-007 ENSP00000354162 ENST00000360909	Q9Y4D1 [Direct mapping] Disheveled-associated activator of morphogenesis 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0003779 [actin binding] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007264 [small GTPase mediated signal transduction] GO:0016020 [membrane] GO:0016043 [cellular component organization] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] GO:0042802 [identical protein binding] Show all	1068 aa 122.3 kDa	No	0
DAAM1-011 ENSP00000450498 ENST00000556135	G3V275 [Direct mapping] Disheveled-associated activator of morphogenesis 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005488 [binding] GO:0017048 [Rho GTPase binding] GO:0030036 [actin cytoskeleton organization] Show all	96 aa 11.3 kDa	No	0