Expression of BDKRB1 in cancer - Summary

CANCER ATLAS

Gene description

Bradykinin receptor B1

Protein class

G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA002935

GENE INFORMATION
Gene name	BDKRB1 (HGNC Symbol)
Synonyms	B1BKR, BKR1, bradyb1
Description	Bradykinin receptor B1 (HGNC Symbol)
Entrez gene summary	Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Chromosome	14
Cytoband	q32.2
Chromosome location (bp)	96255824 - 96268967
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100739 (version 83.38)
Entrez gene	623
UniProt	P46663 (UniProt - Evidence at protein level)
neXtProt	NX_P46663
Antibodypedia	BDKRB1 antibodies

PROTEIN BROWSER

BDKRB1-001	BDKRB1-002	BDKRB1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BDKRB1-001 ENSP00000216629 ENST00000216629	P46663 [Direct mapping] B1 bradykinin receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0001933 [negative regulation of protein phosphorylation] GO:0002687 [positive regulation of leukocyte migration] GO:0004930 [G-protein coupled receptor activity] GO:0004947 [bradykinin receptor activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway] GO:0009612 [response to mechanical stimulus] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0019233 [sensory perception of pain] GO:0030308 [negative regulation of cell growth] GO:0032496 [response to lipopolysaccharide] GO:0042277 [peptide binding] GO:0043005 [neuron projection] GO:0045776 [negative regulation of blood pressure] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] Show all	353 aa 40.5 kDa	No	7
BDKRB1-002 ENSP00000452064 ENST00000553356	G3V4Y2 [Direct mapping] B1 bradykinin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004947 [bradykinin receptor activity] GO:0006954 [inflammatory response] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009612 [response to mechanical stimulus] GO:0016021 [integral component of membrane] Show all	284 aa 32.4 kDa	No	6
BDKRB1-201 ENSP00000479276 ENST00000611804	P46663 [Direct mapping] B1 bradykinin receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0009612 [response to mechanical stimulus] GO:0016021 [integral component of membrane] Show all	353 aa 40.5 kDa	No	7