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VRK1

GENERAL INFORMATION

Gene name

 VRK1

Gene description

 Vaccinia related kinase 1

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in proliferating cells, abundant expression in cells in seminiferous ducts, bone marrow, and subsets of lymphoid cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA000660 , HPA017929
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 VRK1

Synonyms

Description

 Vaccinia related kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q32.2

Chromosome location (bp)

 96797304 - 96931722

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100749 (version 83.38)

Entrez gene

 7443

UniProt

 Q99986 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99986

Antibodypedia

 VRK1 antibodies

PROTEIN BROWSER
VRK1-001
VRK1-003
VRK1-005
VRK1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VRK1-001
ENSP00000216639
ENST00000216639
Q99986 [Direct mapping]
Serine/threonine-protein kinase VRK1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CK1 Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005795 [Golgi stack]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0007067 [mitotic nuclear division]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0007084 [mitotic nuclear envelope reassembly]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0019901 [protein kinase binding]
GO:0031493 [nucleosomal histone binding]
GO:0035175 [histone kinase activity (H3-S10 specific)]
GO:0043987 [histone H3-S10 phosphorylation]
GO:0046777 [protein autophosphorylation]
GO:0051301 [cell division]
GO:0072354 [histone kinase activity (H3-T3 specific)]
GO:0072355 [histone H3-T3 phosphorylation]
GO:0090166 [Golgi disassembly]
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 396 aa
45.5 kDa 		No 0
VRK1-003
ENSP00000450820
ENST00000557222
H0YJ50 [Direct mapping]
Serine/threonine-protein kinase VRK1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
Show all
 232 aa
26.6 kDa 		No 0
VRK1-005
ENSP00000451412
ENST00000553683
H0YJF7 [Direct mapping]
Serine/threonine-protein kinase VRK1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
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 65 aa
7.4 kDa 		No 0
VRK1-006
ENSP00000451682
ENST00000557352
H0YJJ9 [Direct mapping]
Serine/threonine-protein kinase VRK1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016021 [integral component of membrane]
GO:0016055 [Wnt signaling pathway]
Show all
 176 aa
19.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.