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Cancer tissues displayed nuclear immunoreactivity, mainly of weak to moderate intensity. Several colorectal cancers and a few breast cancers were strongly positive, while most liver cancers, endometrial cancers and cervical cancers were negative.
Most cancers showed weak to moderate nuclear staining. Strong nuclear positivity was observed in a few cancer e.g. urothelial cancers, gliomas and carcinoids. Hepatocellular carcinomas and most renal cancers were negative.
GENE INFORMATION
Gene name
YY1 (HGNC Symbol)
Synonyms
DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1
Description
YY1 transcription factor (HGNC Symbol)
Entrez gene summary
YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
P25490 [Direct mapping] Transcriptional repressor protein YY1
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Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000400 [four-way junction DNA binding] GO:0000724 [double-strand break repair via homologous recombination] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001158 [enhancer sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006403 [RNA localization] GO:0006974 [cellular response to DNA damage stimulus] GO:0007283 [spermatogenesis] GO:0008270 [zinc ion binding] GO:0009952 [anterior/posterior pattern specification] GO:0010225 [response to UV-C] GO:0010628 [positive regulation of gene expression] GO:0010629 [negative regulation of gene expression] GO:0016363 [nuclear matrix] GO:0030154 [cell differentiation] GO:0031011 [Ino80 complex] GO:0031519 [PcG protein complex] GO:0034644 [cellular response to UV] GO:0034696 [response to prostaglandin F] GO:0042826 [histone deacetylase binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046332 [SMAD binding] GO:0046872 [metal ion binding] GO:0048593 [camera-type eye morphogenesis] GO:0051276 [chromosome organization] GO:0071347 [cellular response to interleukin-1]