Cell atlas - TRIP11 - The Human Protein Atlas

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TRIP11

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Nucleus

Human cell
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TRIP11
Gene description	Thyroid hormone receptor interactor 11
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the nucleus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (validated)
Additional location	In addition localized to the Nucleus (approved)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA002570 , HPA070684
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the nucleus.

Main location

Golgi apparatus (validated)

Additional location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002570	A-431	Golgi apparatus
	HPA002570	U-2 OS	Nucleus
	HPA002570	U-2 OS	Golgi apparatus
	HPA002570	U-251 MG	Golgi apparatus
	HPA070684	HaCaT	Nuclear speckles
	HPA070684	HaCaT	Golgi apparatus
	HPA070684	MCF7	Nuclear speckles
	HPA070684	MCF7	Golgi apparatus
	HPA070684	U-2 OS	Golgi apparatus

GENE INFORMATION
Gene name	TRIP11 (HGNC Symbol)
Synonyms	CEV14, GMAP-210, GMAP210, Trip230
Description	Thyroid hormone receptor interactor 11 (HGNC Symbol)
Entrez gene summary	This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]
Chromosome	14
Cytoband	q32.12
Chromosome location (bp)	91965991 - 92040896
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100815 (version 83.38)
Entrez gene	9321
UniProt	Q15643 (UniProt - Evidence at protein level)
neXtProt	NX_Q15643
Antibodypedia	TRIP11 antibodies

PROTEIN BROWSER

TRIP11-001	TRIP11-002	TRIP11-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRIP11-001 ENSP00000267622 ENST00000267622	Q15643 [Direct mapping] Thyroid receptor-interacting protein 11 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000042 [protein targeting to Golgi] GO:0000139 [Golgi membrane] GO:0002079 [inner acrosomal membrane] GO:0002080 [acrosomal membrane] GO:0002081 [outer acrosomal membrane] GO:0003281 [ventricular septum development] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005794 [Golgi apparatus] GO:0005801 [cis-Golgi network] GO:0005856 [cytoskeleton] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006996 [organelle organization] GO:1903506 [regulation of nucleic acid-templated transcription] Show all	1979 aa 227.6 kDa	No	0
TRIP11-002 ENSP00000451032 ENST00000554357	H0YJ97 [Direct mapping] Thyroid receptor-interacting protein 11 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000042 [protein targeting to Golgi] GO:0005515 [protein binding] GO:0005622 [intracellular] Show all	1695 aa 195.7 kDa	No	0
TRIP11-005 ENSP00000451944 ENST00000555516	G3V4R7 [Direct mapping] Thyroid receptor-interacting protein 11 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		67 aa 7.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.