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PSMA6

CANCER ATLAS

Gene description

 Proteasome subunit alpha 6

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003049

GENE INFORMATION

Gene name

 PSMA6 (HGNC Symbol)

Synonyms

 IOTA, MGC22756, MGC2333, MGC23846, p27K, PROS27

Description

 Proteasome subunit alpha 6 (HGNC Symbol)

Entrez gene summary

 The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

Chromosome

 14

Cytoband

 q13.2

Chromosome location (bp)

 35278633 - 35317493

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100902 (version 83.38)

Entrez gene

 5687

UniProt

 P60900 (UniProt - Evidence at protein level)

neXtProt

 NX_P60900

Antibodypedia

 PSMA6 antibodies

PROTEIN BROWSER
PSMA6-001
PSMA6-002
PSMA6-004
PSMA6-010
PSMA6-012
PSMA6-013
PSMA6-201
PSMA6-202
PSMA6-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PSMA6-001
ENSP00000261479
ENST00000261479
P60900 [Direct mapping]
Proteasome subunit alpha type-6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Threonine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0003723 [RNA binding]
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005839 [proteasome core complex]
GO:0005844 [polysome]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035639 [purine ribonucleoside triphosphate binding]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050727 [regulation of inflammatory response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051059 [NF-kappaB binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 246 aa
27.4 kDa 		No 0
PSMA6-002
ENSP00000444844
ENST00000540871
P60900 [Direct mapping]
Proteasome subunit alpha type-6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Threonine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0003723 [RNA binding]
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005839 [proteasome core complex]
GO:0005844 [polysome]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035639 [purine ribonucleoside triphosphate binding]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050727 [regulation of inflammatory response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051059 [NF-kappaB binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 227 aa
25.3 kDa 		No 0
PSMA6-004
ENSP00000452566
ENST00000555764
P60900 [Direct mapping]
Proteasome subunit alpha type-6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Threonine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0003723 [RNA binding]
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005839 [proteasome core complex]
GO:0005844 [polysome]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035639 [purine ribonucleoside triphosphate binding]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050727 [regulation of inflammatory response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051059 [NF-kappaB binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 167 aa
18.8 kDa 		No 0
PSMA6-010
ENSP00000452603
ENST00000553809
G3V5Z7 [Direct mapping]
Proteasome subunit alpha type
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005839 [proteasome core complex]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 252 aa
28.1 kDa 		No 0
PSMA6-012
ENSP00000451171
ENST00000556221
H0YJC4 [Direct mapping]
Proteasome subunit alpha type-6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005839 [proteasome core complex]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 85 aa
9.2 kDa 		No 0
PSMA6-013
ENSP00000450528
ENST00000556506
G3V295 [Direct mapping]
Proteasome subunit alpha type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005839 [proteasome core complex]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 203 aa
22.8 kDa 		No 0
PSMA6-201
ENSP00000479620
ENST00000622405
P60900 [Direct mapping]
Proteasome subunit alpha type-6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Threonine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0003723 [RNA binding]
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005839 [proteasome core complex]
GO:0005844 [polysome]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035639 [purine ribonucleoside triphosphate binding]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050727 [regulation of inflammatory response]
GO:0050852 [T cell receptor signaling pathway]
GO:0051059 [NF-kappaB binding]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 167 aa
18.8 kDa 		No 0
PSMA6-202
ENSP00000485817
ENST00000627895
G3V3U4 [Direct mapping]
Proteasome subunit alpha type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005839 [proteasome core complex]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 107 aa
11.6 kDa 		No 0
PSMA6-203
ENSP00000485776
ENST00000628955
G3V2S7 [Direct mapping]
Proteasome subunit alpha type-6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0005634 [nucleus]
GO:0005839 [proteasome core complex]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
Show all
 67 aa
7.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.