Cell atlas - RABGGTA - The Human Protein Atlas

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RABGGTA

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS siRNA

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	RABGGTA
Gene description	Rab geranylgeranyltransferase, alpha subunit
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA043488
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ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA043488	A-431	Nucleoplasm
HPA043488	U-2 OS	Nucleoplasm
HPA043488	U-251 MG	Nucleoplasm

siRNA VALIDATION

Relative fluorescence intensity (RFI)

Antibody

HPA043488

siRNA validation

Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 2

RFI

75%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail 10x	Thumbnail 40x	Antibody	Sample	Cell line
		HPA043488	siRNA 2	U-2 OS
		HPA043488	scrambled	U-2 OS

GENE INFORMATION
Gene name	RABGGTA (HGNC Symbol)
Synonyms	PTAR3
Description	Rab geranylgeranyltransferase, alpha subunit (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q12
Chromosome location (bp)	24265538 - 24271739
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100949 (version 83.38)
Entrez gene	5875
UniProt	Q92696 (UniProt - Evidence at protein level)
neXtProt	NX_Q92696
Antibodypedia	RABGGTA antibodies

PROTEIN BROWSER

RABGGTA-002	RABGGTA-003	RABGGTA-009	RABGGTA-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RABGGTA-002 ENSP00000216840 ENST00000216840	Q92696 [Direct mapping] Geranylgeranyl transferase type-2 subunit alpha Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004663 [Rab geranylgeranyltransferase activity] GO:0005515 [protein binding] GO:0005968 [Rab-protein geranylgeranyltransferase complex] GO:0006464 [cellular protein modification process] GO:0007601 [visual perception] GO:0008270 [zinc ion binding] GO:0008318 [protein prenyltransferase activity] GO:0017137 [Rab GTPase binding] GO:0018342 [protein prenylation] GO:0018344 [protein geranylgeranylation] Show all	567 aa 65.1 kDa	No	0
RABGGTA-003 ENSP00000382341 ENST00000399409	Q92696 [Direct mapping] Geranylgeranyl transferase type-2 subunit alpha Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004663 [Rab geranylgeranyltransferase activity] GO:0005515 [protein binding] GO:0005968 [Rab-protein geranylgeranyltransferase complex] GO:0006464 [cellular protein modification process] GO:0007601 [visual perception] GO:0008270 [zinc ion binding] GO:0008318 [protein prenyltransferase activity] GO:0017137 [Rab GTPase binding] GO:0018342 [protein prenylation] GO:0018344 [protein geranylgeranylation] Show all	567 aa 65.1 kDa	No	0
RABGGTA-009 ENSP00000453596 ENST00000560521	H0YMG5 [Direct mapping] Geranylgeranyl transferase type-2 subunit alpha Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	175 aa 19.5 kDa	No	0
RABGGTA-012 ENSP00000453201 ENST00000560777	H0YLG7 [Direct mapping] Geranylgeranyl transferase type-2 subunit alpha Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	176 aa 19.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.