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Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
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Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001569 [patterning of blood vessels] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007507 [heart development] GO:0008134 [transcription factor binding] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0033173 [calcineurin-NFAT signaling cascade] GO:0034644 [cellular response to UV] GO:0035562 [negative regulation of chromatin binding] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043065 [positive regulation of apoptotic process] GO:0045111 [intermediate filament cytoskeleton] GO:0045333 [cellular respiration] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048167 [regulation of synaptic plasticity] GO:0050774 [negative regulation of dendrite morphogenesis] GO:0051145 [smooth muscle cell differentiation] GO:0055001 [muscle cell development] GO:0071285 [cellular response to lithium ion] GO:2000297 [negative regulation of synapse maturation] GO:2001235 [positive regulation of apoptotic signaling pathway]
Q14934 [Direct mapping] Nuclear factor of activated T-cells, cytoplasmic 4
Show all
Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0045111 [intermediate filament cytoskeleton]