Expression of ABHD12 in cancer - Summary

CANCER ATLAS

Gene description

Abhydrolase domain containing 12

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026866

GENE INFORMATION
Gene name	ABHD12 (HGNC Symbol)
Synonyms	ABHD12A, BEM46L2, C20orf22, dJ965G21.2, DKFZP434P106
Description	Abhydrolase domain containing 12 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jan 2011]
Chromosome	20
Cytoband	p11.21
Chromosome location (bp)	25294743 - 25390983
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100997 (version 83.38)
Entrez gene	26090
UniProt	Q8N2K0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N2K0
Antibodypedia	ABHD12 antibodies

PROTEIN BROWSER

ABHD12-001	ABHD12-002	ABHD12-005	ABHD12-006	ABHD12-008	ABHD12-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABHD12-001 ENSP00000341408 ENST00000339157	Q8N2K0 [Direct mapping] Monoacylglycerol lipase ABHD12 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0030168 [platelet activation] GO:0046464 [acylglycerol catabolic process] GO:0047372 [acylglycerol lipase activity] Show all	398 aa 45.1 kDa	No	1
ABHD12-002 ENSP00000365725 ENST00000376542	Q8N2K0 [Direct mapping] Monoacylglycerol lipase ABHD12 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0006660 [phosphatidylserine catabolic process] GO:0007596 [blood coagulation] GO:0007628 [adult walking behavior] GO:0010996 [response to auditory stimulus] GO:0016021 [integral component of membrane] GO:0030168 [platelet activation] GO:0032281 [AMPA glutamate receptor complex] GO:0046464 [acylglycerol catabolic process] GO:0047372 [acylglycerol lipase activity] Show all	404 aa 45.6 kDa	No	1
ABHD12-005 ENSP00000413311 ENST00000450393	Q5T712 [Direct mapping] Monoacylglycerol lipase ABHD12 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	187 aa 21.2 kDa	No	1
ABHD12-006 ENSP00000459495 ENST00000491682	I3L294 [Direct mapping] Monoacylglycerol lipase ABHD12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		159 aa 18 kDa	No	0
ABHD12-008 ENSP00000460950 ENST00000471287	I3L440 [Direct mapping] Monoacylglycerol lipase ABHD12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		105 aa 11.8 kDa	No	0
ABHD12-010 ENSP00000459121 ENST00000576316	I3L1V0 [Direct mapping] Monoacylglycerol lipase ABHD12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		194 aa 21 kDa	No	0