Cell atlas - MYBL2 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MYBL2
Gene description	V-myb avian myeloblastosis viral oncogene homolog-like 2
Protein class	Cancer-related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Cytosol (validated)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. CAB017114 , HPA055416
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (validated)

Additional location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation
CAB017114	A-431	Nucleoplasm
CAB017114	A-431	Cytosol
CAB017114	U-2 OS	Nucleoplasm
CAB017114	U-2 OS	Cytosol
CAB017114	U-251 MG	Nucleoplasm
CAB017114	U-251 MG	Cytosol
HPA055416	A-431	No staining
HPA055416	U-2 OS	No staining
HPA055416	U-251 MG	Nucleoplasm	Intensity

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000017861 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA055416	NIH 3T3	No staining

GENE INFORMATION
Gene name	MYBL2 (HGNC Symbol)
Synonyms	B-MYB, BMYB
Description	V-myb avian myeloblastosis viral oncogene homolog-like 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	43667019 - 43716496
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101057 (version 83.38)
Entrez gene	4605
UniProt	P10244 (UniProt - Evidence at protein level)
neXtProt	NX_P10244
Antibodypedia	MYBL2 antibodies

PROTEIN BROWSER

MYBL2-001	MYBL2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYBL2-001 ENSP00000217026 ENST00000217026	P10244 [Direct mapping] Myb-related protein B Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0031523 [Myb complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051726 [regulation of cell cycle] GO:0090307 [mitotic spindle assembly] Show all	700 aa 78.8 kDa	No	0
MYBL2-201 ENSP00000380072 ENST00000396863	P10244 [Direct mapping] Myb-related protein B Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051726 [regulation of cell cycle] Show all	676 aa 75.9 kDa	No	0