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SLA2

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GENERAL INFORMATION

Gene name

 SLA2

Gene description

 Src-like-adaptor 2

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the Golgi apparatus, nucleoplasm & vesicles.

RNA cell category

 Cell line enriched (HEL)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved), Golgi apparatus (approved), Vesicles (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 2 antibodies.
HPA053746 , HPA058217
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HEL)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the Golgi apparatus, nucleoplasm & vesicles.

Main location

 Nucleoplasm (approved), Golgi apparatus (approved), Vesicles (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053746 CACO-2 Nucleoplasm
Golgi apparatus Intensity
HPA053746 Hep G2 Nucleoplasm
Golgi apparatus Intensity
HPA053746 U-2 OS Golgi apparatus
HPA058217 CACO-2 Nucleoplasm
Golgi apparatus
HPA058217 Hep G2 Nucleoplasm
Golgi apparatus
Vesicles
HPA058217 U-2 OS Nucleoplasm
Golgi apparatus
Vesicles

GENE INFORMATION

Gene name

 SLA2 (HGNC Symbol)

Synonyms

 C20orf156, FLJ21992, SLAP-2

Description

 Src-like-adaptor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q11.23

Chromosome location (bp)

 36612318 - 36646216

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101082 (version 83.38)

Entrez gene

 84174

UniProt

 Q9H6Q3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H6Q3

Antibodypedia

 SLA2 antibodies

PROTEIN BROWSER
SLA2-001
SLA2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLA2-001
ENSP00000262866
ENST00000262866
Q9H6Q3 [Direct mapping]
Src-like-adapter 2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005770 [late endosome]
GO:0005886 [plasma membrane]
GO:0009967 [positive regulation of signal transduction]
GO:0010008 [endosome membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019724 [B cell mediated immunity]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0047485 [protein N-terminus binding]
GO:0050776 [regulation of immune response]
GO:0050849 [negative regulation of calcium-mediated signaling]
GO:0050851 [antigen receptor-mediated signaling pathway]
GO:0050869 [negative regulation of B cell activation]
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 261 aa
28.6 kDa 		No 0
SLA2-002
ENSP00000353890
ENST00000360672
Q9H6Q3 [Direct mapping]
Src-like-adapter 2
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0009967 [positive regulation of signal transduction]
GO:0010008 [endosome membrane]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0019724 [B cell mediated immunity]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042110 [T cell activation]
GO:0047485 [protein N-terminus binding]
GO:0050776 [regulation of immune response]
GO:0050849 [negative regulation of calcium-mediated signaling]
GO:0050851 [antigen receptor-mediated signaling pathway]
GO:0050869 [negative regulation of B cell activation]
Show all
 210 aa
23.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.