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NFATC2

GENERAL INFORMATION

Gene name

 NFATC2

Gene description

 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA008789 , HPA024369 , CAB018567
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NFATC2 (HGNC Symbol)

Synonyms

 NF-ATP, NFAT1, NFATp

Description

 Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]

Chromosome

 20

Cytoband

 q13.2

Chromosome location (bp)

 51386957 - 51562831

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101096 (version 83.38)

Entrez gene

 4773

UniProt

 Q13469 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13469

Antibodypedia

 NFATC2 antibodies

PROTEIN BROWSER
NFATC2-001
NFATC2-002
NFATC2-004
NFATC2-005
NFATC2-006
NFATC2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFATC2-001
ENSP00000360619
ENST00000371564
Q13469 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 2
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030890 [positive regulation of B cell proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042493 [response to drug]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050853 [B cell receptor signaling pathway]
Show all
 921 aa
99.8 kDa 		No 0
NFATC2-002
ENSP00000379330
ENST00000396009
Q13469 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 2
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001816 [cytokine production]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008134 [transcription factor binding]
GO:0010628 [positive regulation of gene expression]
GO:0014904 [myotube cell development]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030529 [ribonucleoprotein complex]
GO:0030890 [positive regulation of B cell proliferation]
GO:0033173 [calcineurin-NFAT signaling cascade]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042493 [response to drug]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0044798 [nuclear transcription factor complex]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050853 [B cell receptor signaling pathway]
GO:1901741 [positive regulation of myoblast fusion]
Show all
 925 aa
100.1 kDa 		No 0
NFATC2-004
ENSP00000396471
ENST00000414705
Q13469 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 2
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030890 [positive regulation of B cell proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042493 [response to drug]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050853 [B cell receptor signaling pathway]
Show all
 901 aa
97.7 kDa 		No 0
NFATC2-005
ENSP00000477370
ENST00000609943
Q13469 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 2
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030890 [positive regulation of B cell proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042493 [response to drug]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050853 [B cell receptor signaling pathway]
Show all
 905 aa
98.1 kDa 		No 0
NFATC2-006
ENSP00000477342
ENST00000609507
Q13469 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 2
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030890 [positive regulation of B cell proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042493 [response to drug]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050853 [B cell receptor signaling pathway]
Show all
 702 aa
76.7 kDa 		No 0
NFATC2-007
ENSP00000477142
ENST00000610033
Q13469 [Direct mapping]
Nuclear factor of activated T-cells, cytoplasmic 2
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0030890 [positive regulation of B cell proliferation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042493 [response to drug]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0050853 [B cell receptor signaling pathway]
Show all
 702 aa
76.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.