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DNAJC5

GENERAL INFORMATION

Gene name

 DNAJC5

Gene description

 DnaJ (Hsp40) homolog, subfamily C, member 5

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression in most tissues, highest expression in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA012737 , HPA013154
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DNAJC5 (HGNC Symbol)

Synonyms

 CLN4, DNAJC5A, FLJ00118, FLJ13070

Description

 DnaJ (Hsp40) homolog, subfamily C, member 5 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. The encoded protein plays a role in membrane trafficking and protein folding, and has been shown to have anti-neurodegenerative properties. The encoded protein is known to play a role in cystic fibrosis and Huntington's disease. A pseudogene of this gene is located on the short arm of chromosome 8. [provided by RefSeq, Nov 2010]

Chromosome

 20

Cytoband

 q13.33

Chromosome location (bp)

 63895182 - 63936031

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101152 (version 83.38)

Entrez gene

 80331

UniProt

 Q9H3Z4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H3Z4

Antibodypedia

 DNAJC5 antibodies

PROTEIN BROWSER
DNAJC5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DNAJC5-001
ENSP00000354111
ENST00000360864
Q9H3Z4 [Direct mapping]
DnaJ homolog subfamily C member 5
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0006887 [exocytosis]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0008021 [synaptic vesicle]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0042470 [melanosome]
GO:0043008 [ATP-dependent protein binding]
GO:0043195 [terminal bouton]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0045055 [regulated secretory pathway]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
GO:0070062 [extracellular exosome]
Show all
 198 aa
22.1 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.