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CTSZ

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GENERAL INFORMATION

Gene name

 CTSZ

Gene description

 Cathepsin Z

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA049876
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA049876 A-431 Vesicles
HPA049876 CACO-2 Vesicles
HPA049876 U-2 OS Vesicles

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000016256 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA049876 NIH 3T3 No staining

GENE INFORMATION

Gene name

 CTSZ (HGNC Symbol)

Synonyms

 CTSX

Description

 Cathepsin Z (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]

Chromosome

 20

Cytoband

 q13.32

Chromosome location (bp)

 58995185 - 59007247

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101160 (version 83.38)

Entrez gene

 1522

UniProt

 Q9UBR2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBR2

Antibodypedia

 CTSZ antibodies

PROTEIN BROWSER
CTSZ-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTSZ-001
ENSP00000217131
ENST00000217131
Q9UBR2 [Direct mapping]
Cathepsin Z
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0002003 [angiotensin maturation]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008234 [cysteine-type peptidase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030134 [ER to Golgi transport vesicle]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0060441 [epithelial tube branching involved in lung morphogenesis]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
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 303 aa
33.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.