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TUBB1

GENERAL INFORMATION

Gene name

 TUBB1

Gene description

 Tubulin, beta 1 class VI

Protein class

 Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (spleen, bone marrow, lung, testis, placenta)
GTEx:Tissue enhanced (spleen, lung)
FANTOM5:Tissue enhanced (spleen)

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.

Reliability score

 Approved based on 3 antibodies.
HPA043640 , HPA046280 , CAB004286
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, bone marrow, lung, testis, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)

GENE INFORMATION

Gene name

 TUBB1 (HGNC Symbol)

Synonyms

 dJ543J19.4

Description

 Tubulin, beta 1 class VI (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010]

Chromosome

 20

Cytoband

 q13.32

Chromosome location (bp)

 59019254 - 59026654

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101162 (version 83.38)

Entrez gene

 81027

UniProt

 Q9H4B7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H4B7

Antibodypedia

 TUBB1 antibodies

PROTEIN BROWSER
TUBB1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBB1-001
ENSP00000217133
ENST00000217133
Q9H4B7 [Direct mapping]
Tubulin beta-1 chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0007017 [microtubule-based process]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051225 [spindle assembly]
GO:0051258 [protein polymerization]
GO:0070062 [extracellular exosome]
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 451 aa
50.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.