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AVP

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GENERAL INFORMATION

Gene name

 AVP

Gene description

 Arginine vasopressin

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (NB-4)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (NB-4)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 AVP (HGNC Symbol)

Synonyms

 ADH, ARVP

Description

 Arginine vasopressin (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20. [provided by RefSeq, Nov 2015]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 3082556 - 3084724

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101200 (version 83.38)

Entrez gene

 551

UniProt

 P01185 (UniProt - Evidence at protein level)

neXtProt

 NX_P01185

Antibodypedia

 AVP antibodies

PROTEIN BROWSER
AVP-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AVP-001
ENSP00000369647
ENST00000380293
P01185 [Direct mapping]
Vasopressin-neurophysin 2-copeptin Arg-vasopressin Neurophysin 2 Copeptin
X5DQP6 [Target identity:100%; Query identity:100%]
Arginine vasopressin (Neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal); Arginine vasopressin isoform B
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0002125 [maternal aggressive behavior]
GO:0003084 [positive regulation of systemic arterial blood pressure]
GO:0003091 [renal water homeostasis]
GO:0004672 [protein kinase activity]
GO:0004871 [signal transducer activity]
GO:0005102 [receptor binding]
GO:0005184 [neuropeptide hormone activity]
GO:0005185 [neurohypophyseal hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007267 [cell-cell signaling]
GO:0007621 [negative regulation of female receptivity]
GO:0007623 [circadian rhythm]
GO:0007625 [grooming behavior]
GO:0007626 [locomotory behavior]
GO:0008284 [positive regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0014049 [positive regulation of glutamate secretion]
GO:0014070 [response to organic cyclic compound]
GO:0030141 [secretory granule]
GO:0030307 [positive regulation of cell growth]
GO:0030425 [dendrite]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031394 [positive regulation of prostaglandin biosynthetic process]
GO:0031894 [V1A vasopressin receptor binding]
GO:0031895 [V1B vasopressin receptor binding]
GO:0032849 [positive regulation of cellular pH reduction]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0033574 [response to testosterone]
GO:0035094 [response to nicotine]
GO:0035176 [social behavior]
GO:0035813 [regulation of renal sodium excretion]
GO:0042310 [vasoconstriction]
GO:0042538 [hyperosmotic salinity response]
GO:0042711 [maternal behavior]
GO:0043027 [cysteine-type endopeptidase inhibitor activity involved in apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043084 [penile erection]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043252 [sodium-independent organic anion transport]
GO:0045471 [response to ethanol]
GO:0045907 [positive regulation of vasoconstriction]
GO:0050891 [multicellular organismal water homeostasis]
GO:0051970 [negative regulation of transmission of nerve impulse]
GO:0055085 [transmembrane transport]
GO:0070371 [ERK1 and ERK2 cascade]
GO:0070528 [protein kinase C signaling]
GO:0090201 [negative regulation of release of cytochrome c from mitochondria]
Show all
 164 aa
17.3 kDa 		Yes 0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.