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RASSF2

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GENERAL INFORMATION

Gene name

 RASSF2

Gene description

 Ras association (RalGDS/AF-6) domain family member 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (U-937)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Cytosol (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA051200
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-937)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (supported)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA051200 A549 Nucleoplasm
Golgi apparatus Intensity
Cytosol
HPA051200 RT4 Nucleoplasm
Cytosol
HPA051200 U-2 OS Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 RASSF2 (HGNC Symbol)

Synonyms

 CENP-34, KIAA0168

Description

 Ras association (RalGDS/AF-6) domain family member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 4780023 - 4823645

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101265 (version 83.38)

Entrez gene

 9770

UniProt

 P50749 (UniProt - Evidence at protein level)

neXtProt

 NX_P50749

Antibodypedia

 RASSF2 antibodies

PROTEIN BROWSER
RASSF2-001
RASSF2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASSF2-001
ENSP00000368710
ENST00000379400
P50749 [Direct mapping]
Ras association domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001503 [ossification]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0038168 [epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045670 [regulation of osteoclast differentiation]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046849 [bone remodeling]
GO:0048872 [homeostasis of number of cells]
GO:0050821 [protein stabilization]
GO:1901222 [regulation of NIK/NF-kappaB signaling]
GO:1901223 [negative regulation of NIK/NF-kappaB signaling]
Show all
 326 aa
37.8 kDa 		No 0
RASSF2-201
ENSP00000368684
ENST00000379376
P50749 [Direct mapping]
Ras association domain-containing protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0050821 [protein stabilization]
Show all
 326 aa
37.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.