Expression of PROKR2 in cancer - Summary

CANCER ATLAS

Gene description

Prokineticin receptor 2

Protein class

Disease related genes, G-protein coupled receptors, Plasma proteins, Potential drug targets, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA047281

GENE INFORMATION
Gene name	PROKR2 (HGNC Symbol)
Synonyms	dJ680N4.3, GPR73b, GPR73L1, GPRg2, KAL3, PKR2
Description	Prokineticin receptor 2 (HGNC Symbol)
Entrez gene summary	Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p12.3
Chromosome location (bp)	5302040 - 5314369
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101292 (version 83.38)
Entrez gene	128674
UniProt	Q8NFJ6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFJ6
Antibodypedia	PROKR2 antibodies

PROTEIN BROWSER

PROKR2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PROKR2-001 ENSP00000217270 ENST00000217270	Q8NFJ6 [Direct mapping] Prokineticin receptor 2 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004983 [neuropeptide Y receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007623 [circadian rhythm] GO:0016021 [integral component of membrane] Show all	384 aa 44 kDa	No	7