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SNPH

GENERAL INFORMATION

Gene name

 SNPH

Gene description

 Syntaphilin

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex)
FANTOM5:Tissue enhanced (hippocampus, brain, caudate)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in several tissues, including processes in brain.

DATA RELIABILITY

Data reliability
description

 Antibody staining in cells/structures not annotated, view images. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA049393
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (hippocampus, brain, caudate)

GENE INFORMATION

Gene name

 SNPH (HGNC Symbol)

Synonyms

 bA314N13.5

Description

 Syntaphilin (HGNC Symbol)

Entrez gene summary

 Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 1266316 - 1309328

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101298 (version 83.38)

Entrez gene

 9751

UniProt

 O15079 (UniProt - Evidence at protein level)

neXtProt

 NX_O15079

Antibodypedia

 SNPH antibodies

PROTEIN BROWSER
SNPH-001
SNPH-002
SNPH-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNPH-001
ENSP00000371291
ENST00000381867
O15079 [Direct mapping]
Syntaphilin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005881 [cytoplasmic microtubule]
GO:0007269 [neurotransmitter secretion]
GO:0016021 [integral component of membrane]
GO:0016081 [synaptic vesicle docking]
GO:0017075 [syntaxin-1 binding]
GO:0030054 [cell junction]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
Show all
 538 aa
58 kDa 		No 1
SNPH-002
ENSP00000371297
ENST00000381873
O15079 [Direct mapping]
Syntaphilin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0007269 [neurotransmitter secretion]
GO:0007420 [brain development]
GO:0016021 [integral component of membrane]
GO:0016081 [synaptic vesicle docking]
GO:0017075 [syntaxin-1 binding]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0031966 [mitochondrial membrane]
GO:0042734 [presynaptic membrane]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045202 [synapse]
Show all
 494 aa
53.5 kDa 		No 1
SNPH-201
ENSP00000479696
ENST00000614659
O15079 [Direct mapping]
Syntaphilin
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005881 [cytoplasmic microtubule]
GO:0007269 [neurotransmitter secretion]
GO:0016021 [integral component of membrane]
GO:0016081 [synaptic vesicle docking]
GO:0017075 [syntaxin-1 binding]
GO:0030054 [cell junction]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
Show all
 538 aa
58 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.