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SEC23B

GENERAL INFORMATION

Gene name

 SEC23B

Gene description

 Sec23 homolog B, COPII coat complex component

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several different tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA008216 , HPA069974
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SEC23B (HGNC Symbol)

Synonyms

 CDA-II, CDAII, CDAN2, HEMPAS

Description

 Sec23 homolog B, COPII coat complex component (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The function of this gene product has been implicated in cargo selection and concentration. Multiple alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]

Chromosome

 20

Cytoband

 p11.23

Chromosome location (bp)

 18507493 - 18561415

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101310 (version 83.38)

Entrez gene

 10483

UniProt

 Q15437 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15437

Antibodypedia

 SEC23B antibodies

PROTEIN BROWSER
SEC23B-001
SEC23B-002
SEC23B-003
SEC23B-004
SEC23B-005
SEC23B-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SEC23B-001
ENSP00000403971
ENST00000450074
Q5QPE2 [Direct mapping]
Protein transport protein Sec23B
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008270 [zinc ion binding]
GO:0030127 [COPII vesicle coat]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 331 aa
37.1 kDa 		No 0
SEC23B-002
ENSP00000366695
ENST00000377475
Q15437 [Direct mapping]
Protein transport protein Sec23B
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008270 [zinc ion binding]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0030127 [COPII vesicle coat]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 767 aa
86.5 kDa 		No 0
SEC23B-003
ENSP00000338844
ENST00000336714
Q15437 [Direct mapping]
Protein transport protein Sec23B
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008270 [zinc ion binding]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0030127 [COPII vesicle coat]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048471 [perinuclear region of cytoplasm]
Show all
 767 aa
86.5 kDa 		No 0
SEC23B-004
ENSP00000366685
ENST00000377465
Q15437 [Direct mapping]
Protein transport protein Sec23B
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008270 [zinc ion binding]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0030127 [COPII vesicle coat]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 767 aa
86.5 kDa 		No 0
SEC23B-005
ENSP00000262544
ENST00000262544
Q15437 [Direct mapping]
Protein transport protein Sec23B
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0008270 [zinc ion binding]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0030127 [COPII vesicle coat]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 767 aa
86.5 kDa 		No 0
SEC23B-008
ENSP00000409882
ENST00000422877
Q5QPE1 [Direct mapping]
Protein transport protein Sec23B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006886 [intracellular protein transport]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0030127 [COPII vesicle coat]
Show all
 246 aa
28.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.