Expression of PDYN in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Prodynorphin

Protein class

Disease related genes, Potential drug targets, Predicted secreted proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Glioma

STAINING SUMMARY

HPA049841	HPA053342

GENE INFORMATION
Gene name	PDYN (HGNC Symbol)
Synonyms	ADCA, PENKB, SCA23
Description	Prodynorphin (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	1978757 - 1994285
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101327 (version 83.38)
Entrez gene	5173
UniProt	P01213 (UniProt - Evidence at protein level)
neXtProt	NX_P01213
Antibodypedia	PDYN antibodies

PROTEIN BROWSER

PDYN-002	PDYN-201	PDYN-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDYN-002 ENSP00000217305 ENST00000217305	P01213 [Direct mapping] Proenkephalin-B Alpha-neoendorphin Beta-neoendorphin Big dynorphin Dynorphin A(1-17) Dynorphin A(1-13) Dynorphin A(1-8) Leu-enkephalin Rimorphin Leumorphin Show all	Transporters Transporter channels and pores Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001515 [opioid peptide activity] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] Show all	254 aa 28.4 kDa	Yes	0
PDYN-201 ENSP00000440185 ENST00000539905	P01213 [Direct mapping] Proenkephalin-B Alpha-neoendorphin Beta-neoendorphin Big dynorphin Dynorphin A(1-17) Dynorphin A(1-13) Dynorphin A(1-8) Leu-enkephalin Rimorphin Leumorphin Show all	Transporters Transporter channels and pores Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001515 [opioid peptide activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] GO:0043025 [neuronal cell body] Show all	254 aa 28.4 kDa	Yes	0
PDYN-202 ENSP00000442259 ENST00000540134	P01213 [Direct mapping] Proenkephalin-B Alpha-neoendorphin Beta-neoendorphin Big dynorphin Dynorphin A(1-17) Dynorphin A(1-13) Dynorphin A(1-8) Leu-enkephalin Rimorphin Leumorphin Show all	Transporters Transporter channels and pores Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001515 [opioid peptide activity] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] Show all	254 aa 28.4 kDa	Yes	0