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PLCB4

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GENERAL INFORMATION

Gene name

 PLCB4

Gene description

 Phospholipase C, beta 4

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the microtubules. In addition localized to the nucleoplasm.

RNA cell category

 Cell line enhanced (RPTEC TERT1, LHCN-M2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Microtubules (approved)

Additional location

 In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA007951
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RPTEC TERT1, LHCN-M2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the microtubules. In addition localized to the nucleoplasm.

Main location

 Microtubules (approved)

Additional location

 Nucleoplasm (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA007951 BJ Nucleoplasm
Microtubules
HPA007951 U-2 OS Nucleoplasm
Microtubules
HPA007951 U-251 MG Microtubules

GENE INFORMATION

Gene name

 PLCB4

Synonyms

Description

 Phospholipase C, beta 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals in the retina. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2010]

Chromosome

 20

Cytoband

Chromosome location (bp)

 9068763 - 9481242

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101333 (version 83.38)

Entrez gene

 5332

UniProt

 Q15147 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15147

Antibodypedia

 PLCB4 antibodies

PROTEIN BROWSER
PLCB4-001
PLCB4-002
PLCB4-004
PLCB4-007
PLCB4-008
PLCB4-011
PLCB4-012
PLCB4-201
PLCB4-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLCB4-001
ENSP00000367754
ENST00000378493
Q15147 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 1175 aa
134.5 kDa 		No 0
PLCB4-002
ENSP00000412982
ENST00000441846
B1AJW3 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
Show all
 110 aa
12.4 kDa 		No 0
PLCB4-004
ENSP00000395753
ENST00000416836
B1AJW1 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
Show all
 60 aa
7.2 kDa 		No 0
PLCB4-007
ENSP00000391614
ENST00000437503
B1AJW2 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
Show all
 81 aa
9.4 kDa 		No 0
PLCB4-008
ENSP00000385805
ENST00000407043
B1AJW4 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0035556 [intracellular signal transduction]
Show all
 113 aa
12.8 kDa 		No 0
PLCB4-011
ENSP00000367762
ENST00000378501
Q15147 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005790 [smooth endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0014069 [postsynaptic density]
GO:0016042 [lipid catabolic process]
GO:0030425 [dendrite]
GO:0035556 [intracellular signal transduction]
GO:0043267 [negative regulation of potassium ion transport]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0051019 [mitogen-activated protein kinase binding]
Show all
 1194 aa
136.1 kDa 		No 0
PLCB4-012
ENSP00000390616
ENST00000414679
Q15147 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 1187 aa
135.8 kDa 		No 0
PLCB4-201
ENSP00000278655
ENST00000278655
Q15147 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 1175 aa
134.5 kDa 		No 0
PLCB4-202
ENSP00000367734
ENST00000378473
Q15147 [Direct mapping]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004629 [phospholipase C activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006629 [lipid metabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0035556 [intracellular signal transduction]
GO:0043647 [inositol phosphate metabolic process]
GO:0044281 [small molecule metabolic process]
Show all
 1187 aa
135.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.