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HCK

GENERAL INFORMATION

Gene name

 HCK

Gene description

 HCK proto-oncogene, Src family tyrosine kinase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (appendix, spleen)
GTEx:Group enriched (spleen, lung)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in subsets of immune cells in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
CAB005195
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (appendix, spleen)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (spleen, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HCK (HGNC Symbol)

Synonyms

 JTK9

Description

 HCK proto-oncogene, Src family tyrosine kinase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

Chromosome

 20

Cytoband

 q11.21

Chromosome location (bp)

 32052188 - 32101856

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101336 (version 83.38)

Entrez gene

 3055

UniProt

 P08631 (UniProt - Evidence at protein level)

neXtProt

 NX_P08631

Antibodypedia

 HCK antibodies

PROTEIN BROWSER
HCK-001
HCK-002
HCK-006
HCK-007
HCK-008
HCK-201
HCK-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HCK-001
ENSP00000365012
ENST00000375852
J3KPD6 [Direct mapping]
Non-specific protein-tyrosine kinase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0030154 [cell differentiation]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 526 aa
59.6 kDa 		No 0
HCK-002
ENSP00000365022
ENST00000375862
H0Y3C5 [Direct mapping]
Non-specific protein-tyrosine kinase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0030154 [cell differentiation]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 525 aa
59.5 kDa 		No 0
HCK-006
ENSP00000429848
ENST00000520553
P08631 [Direct mapping]
Tyrosine-protein kinase HCK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002522 [leukocyte migration involved in immune response]
GO:0002758 [innate immune response-activating signal transduction]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005764 [lysosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007498 [mesoderm development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030133 [transport vesicle]
GO:0030154 [cell differentiation]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043299 [leukocyte degranulation]
GO:0045087 [innate immune response]
GO:0045728 [respiratory burst after phagocytosis]
GO:0046777 [protein autophosphorylation]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050727 [regulation of inflammatory response]
GO:0050764 [regulation of phagocytosis]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071801 [regulation of podosome assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 505 aa
57.3 kDa 		No 0
HCK-007
ENSP00000427757
ENST00000518730
P08631 [Direct mapping]
Tyrosine-protein kinase HCK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002522 [leukocyte migration involved in immune response]
GO:0002758 [innate immune response-activating signal transduction]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005764 [lysosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007498 [mesoderm development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030133 [transport vesicle]
GO:0030154 [cell differentiation]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043299 [leukocyte degranulation]
GO:0045087 [innate immune response]
GO:0045728 [respiratory burst after phagocytosis]
GO:0046777 [protein autophosphorylation]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050727 [regulation of inflammatory response]
GO:0050764 [regulation of phagocytosis]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071801 [regulation of podosome assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 504 aa
57.2 kDa 		No 0
HCK-008
ENSP00000486627
ENST00000629881
P08631 [Direct mapping]
Tyrosine-protein kinase HCK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002522 [leukocyte migration involved in immune response]
GO:0002758 [innate immune response-activating signal transduction]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005764 [lysosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007498 [mesoderm development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030133 [transport vesicle]
GO:0030154 [cell differentiation]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043299 [leukocyte degranulation]
GO:0045087 [innate immune response]
GO:0045728 [respiratory burst after phagocytosis]
GO:0046777 [protein autophosphorylation]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050727 [regulation of inflammatory response]
GO:0050764 [regulation of phagocytosis]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071801 [regulation of podosome assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 505 aa
57.3 kDa 		No 0
HCK-201
ENSP00000444986
ENST00000534862
J3KPD6 [Direct mapping]
Non-specific protein-tyrosine kinase
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0006909 [phagocytosis]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0030154 [cell differentiation]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0045087 [innate immune response]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0071375 [cellular response to peptide hormone stimulus]
Show all
 526 aa
59.6 kDa 		No 0
HCK-202
ENSP00000441169
ENST00000538448
P08631 [Direct mapping]
Tyrosine-protein kinase HCK
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002522 [leukocyte migration involved in immune response]
GO:0002758 [innate immune response-activating signal transduction]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005764 [lysosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007498 [mesoderm development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008360 [regulation of cell shape]
GO:0016032 [viral process]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030133 [transport vesicle]
GO:0030154 [cell differentiation]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042995 [cell projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043299 [leukocyte degranulation]
GO:0045087 [innate immune response]
GO:0045728 [respiratory burst after phagocytosis]
GO:0046777 [protein autophosphorylation]
GO:0050690 [regulation of defense response to virus by virus]
GO:0050727 [regulation of inflammatory response]
GO:0050764 [regulation of phagocytosis]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071801 [regulation of podosome assembly]
GO:2000251 [positive regulation of actin cytoskeleton reorganization]
Show all
 505 aa
57.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.