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CRNKL1

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GENERAL INFORMATION

Gene name

 CRNKL1

Gene description

 Crooked neck pre-mRNA splicing factor 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CRNKL1 (HGNC Symbol)

Synonyms

 CLF, Clf1, CRN, SYF3

Description

 Crooked neck pre-mRNA splicing factor 1 (HGNC Symbol)

Entrez gene summary

 The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2013]

Chromosome

 20

Cytoband

 p11.23

Chromosome location (bp)

 20034368 - 20056046

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101343 (version 83.38)

Entrez gene

 51340

UniProt

 Q9BZJ0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZJ0

Antibodypedia

 CRNKL1 antibodies

PROTEIN BROWSER
CRNKL1-001
CRNKL1-002
CRNKL1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRNKL1-001
ENSP00000366544
ENST00000377327
Q5JY65 [Direct mapping]
Crooked neck-like protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006396 [RNA processing]
GO:0006397 [mRNA processing]
Show all
 836 aa
99.2 kDa 		No 0
CRNKL1-002
ENSP00000366557
ENST00000377340
Q9BZJ0 [Direct mapping]
Crooked neck-like protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0071010 [prespliceosome]
GO:0071011 [precatalytic spliceosome]
GO:0071012 [catalytic step 1 spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0071014 [post-mRNA release spliceosomal complex]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 848 aa
100.5 kDa 		No 0
CRNKL1-007
ENSP00000440733
ENST00000536226
Q9BZJ0 [Direct mapping]
Crooked neck-like protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005681 [spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0016607 [nuclear speck]
GO:0044822 [poly(A) RNA binding]
GO:0071010 [prespliceosome]
GO:0071011 [precatalytic spliceosome]
GO:0071012 [catalytic step 1 spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0071014 [post-mRNA release spliceosomal complex]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 687 aa
83.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.