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MAPRE1

GENERAL INFORMATION

Gene name

 MAPRE1

Gene description

 Microtubule-associated protein, RP/EB family, member 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA003600 , CAB009337 , CAB019391
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MAPRE1 (HGNC Symbol)

Synonyms

 EB1

Description

 Microtubule-associated protein, RP/EB family, member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q11.21

Chromosome location (bp)

 32819893 - 32850405

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101367 (version 83.38)

Entrez gene

 22919

UniProt

 Q15691 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15691

Antibodypedia

 MAPRE1 antibodies

PROTEIN BROWSER
MAPRE1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPRE1-001
ENSP00000364721
ENST00000375571
Q15691 [Direct mapping]
Microtubule-associated protein RP/EB family member 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005819 [spindle]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005881 [cytoplasmic microtubule]
GO:0006996 [organelle organization]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell proliferation]
GO:0015630 [microtubule cytoskeleton]
GO:0030981 [cortical microtubule cytoskeleton]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031253 [cell projection membrane]
GO:0035371 [microtubule plus-end]
GO:0035372 [protein localization to microtubule]
GO:0042995 [cell projection]
GO:0044822 [poly(A) RNA binding]
GO:0051010 [microtubule plus-end binding]
GO:0051301 [cell division]
GO:1903033 [positive regulation of microtubule plus-end binding]
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 268 aa
30 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.