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Cancer cells generally showed weak to moderate cytoplasmic and membranous positivity. Strong cytoplasmic positivity was observed in a few cases of gliomas.
GENE INFORMATION
Gene name
JAG1 (HGNC Symbol)
Synonyms
AGS, AHD, AWS, CD339, HJ1, JAGL1
Description
Jagged 1 (HGNC Symbol)
Entrez gene summary
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]