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OXT

GENERAL INFORMATION

Gene name

 OXT

Gene description

 Oxytocin/neurophysin I prepropeptide

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (liver)
GTEx:Tissue enriched (hypothalamus)
FANTOM5:Tissue enhanced (liver)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (liver)

GENE INFORMATION

Gene name

 OXT (HGNC Symbol)

Synonyms

 OT, OT-NPI, OXT-NPI

Description

 Oxytocin/neurophysin I prepropeptide (HGNC Symbol)

Entrez gene summary

 This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 3071620 - 3072517

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101405 (version 83.38)

Entrez gene

 5020

UniProt

 P01178 (UniProt - Evidence at protein level)

neXtProt

 NX_P01178

Antibodypedia

 OXT antibodies

PROTEIN BROWSER
OXT-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OXT-001
ENSP00000217386
ENST00000217386
P01178 [Direct mapping]
Oxytocin-neurophysin 1 Oxytocin Neurophysin 1
X5D7M6 [Target identity:100%; Query identity:100%]
Oxytocin, prepro-(Neurophysin I); Oxytocin/neurophysin I prepropeptide isoform A
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   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Show all
GO:0001975 [response to amphetamine]
GO:0002027 [regulation of heart rate]
GO:0002125 [maternal aggressive behavior]
GO:0005185 [neurohypophyseal hormone activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007507 [heart development]
GO:0007565 [female pregnancy]
GO:0007613 [memory]
GO:0007625 [grooming behavior]
GO:0009744 [response to sucrose]
GO:0010701 [positive regulation of norepinephrine secretion]
GO:0014070 [response to organic cyclic compound]
GO:0014823 [response to activity]
GO:0030141 [secretory granule]
GO:0030431 [sleep]
GO:0031855 [oxytocin receptor binding]
GO:0032308 [positive regulation of prostaglandin secretion]
GO:0032355 [response to estradiol]
GO:0032526 [response to retinoic acid]
GO:0032570 [response to progesterone]
GO:0034695 [response to prostaglandin E]
GO:0035176 [social behavior]
GO:0035811 [negative regulation of urine volume]
GO:0035815 [positive regulation of renal sodium excretion]
GO:0042220 [response to cocaine]
GO:0042538 [hyperosmotic salinity response]
GO:0042711 [maternal behavior]
GO:0042713 [sperm ejaculation]
GO:0042755 [eating behavior]
GO:0042756 [drinking behavior]
GO:0043195 [terminal bouton]
GO:0043434 [response to peptide hormone]
GO:0044058 [regulation of digestive system process]
GO:0045472 [response to ether]
GO:0045776 [negative regulation of blood pressure]
GO:0045777 [positive regulation of blood pressure]
GO:0045778 [positive regulation of ossification]
GO:0045925 [positive regulation of female receptivity]
GO:0048545 [response to steroid hormone]
GO:0050806 [positive regulation of synaptic transmission]
GO:0051384 [response to glucocorticoid]
GO:0051591 [response to cAMP]
GO:0051602 [response to electrical stimulus]
GO:0051930 [regulation of sensory perception of pain]
GO:0051965 [positive regulation of synapse assembly]
GO:0060179 [male mating behavior]
GO:0060406 [positive regulation of penile erection]
GO:0060450 [positive regulation of hindgut contraction]
GO:0060455 [negative regulation of gastric acid secretion]
GO:0070474 [positive regulation of uterine smooth muscle contraction]
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 125 aa
12.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.