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Most cancer cells showed moderate to strong cytoplasmic positivity with a granular pattern. Gliomas and skin cancers as well as most testicular, liver and renal cancers were negative.
Cancer tissues showed moderate to strong granular cytoplasmic, membranous and nucleolar staining.
GENE INFORMATION
Gene name
CHMP4B (HGNC Symbol)
Synonyms
C20orf178, dJ553F4.4, Shax1, SNF7-2, VPS32B
Description
Charged multivesicular body protein 4B (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.[provided by RefSeq, Oct 2009]