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CST3

CANCER ATLAS

Gene description

 Cystatin C

Protein class

 Cancer-related genes, Disease related genes, Plasma proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA013143
CAB000118

GENE INFORMATION

Gene name

 CST3

Synonyms

Description

 Cystatin C (HGNC Symbol)

Entrez gene summary

 The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014]

Chromosome

 20

Cytoband

 p11.21

Chromosome location (bp)

 23626706 - 23638473

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101439 (version 83.38)

Entrez gene

 1471

UniProt

 P01034 (UniProt - Evidence at protein level)

neXtProt

 NX_P01034

Antibodypedia

 CST3 antibodies

PROTEIN BROWSER
CST3-001
CST3-002
CST3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CST3-001
ENSP00000366124
ENST00000376925
P01034 [Direct mapping]
Cystatin-C
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0002020 [protease binding]
GO:0004866 [endopeptidase inhibitor activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006952 [defense response]
GO:0010466 [negative regulation of peptidase activity]
GO:0010711 [negative regulation of collagen catabolic process]
GO:0010716 [negative regulation of extracellular matrix disassembly]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0034103 [regulation of tissue remodeling]
GO:0042802 [identical protein binding]
GO:0043206 [extracellular fibril organization]
GO:0044267 [cellular protein metabolic process]
GO:0045861 [negative regulation of proteolysis]
GO:0060311 [negative regulation of elastin catabolic process]
GO:0060313 [negative regulation of blood vessel remodeling]
GO:0070062 [extracellular exosome]
Show all
 146 aa
15.8 kDa 		Yes 0
CST3-002
ENSP00000381448
ENST00000398411
P01034 [Direct mapping]
Cystatin-C
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0001654 [eye development]
GO:0001666 [response to hypoxia]
GO:0001775 [cell activation]
GO:0002020 [protease binding]
GO:0004866 [endopeptidase inhibitor activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005764 [lysosome]
GO:0005771 [multivesicular body]
GO:0005783 [endoplasmic reticulum]
GO:0006915 [apoptotic process]
GO:0006952 [defense response]
GO:0006979 [response to oxidative stress]
GO:0007420 [brain development]
GO:0007431 [salivary gland development]
GO:0007566 [embryo implantation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008584 [male gonad development]
GO:0009636 [response to toxic substance]
GO:0009743 [response to carbohydrate]
GO:0010035 [response to inorganic substance]
GO:0010466 [negative regulation of peptidase activity]
GO:0010711 [negative regulation of collagen catabolic process]
GO:0010716 [negative regulation of extracellular matrix disassembly]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0014070 [response to organic cyclic compound]
GO:0030414 [peptidase inhibitor activity]
GO:0030424 [axon]
GO:0031667 [response to nutrient levels]
GO:0031965 [nuclear membrane]
GO:0031982 [vesicle]
GO:0032355 [response to estradiol]
GO:0034103 [regulation of tissue remodeling]
GO:0034599 [cellular response to oxidative stress]
GO:0042493 [response to drug]
GO:0042747 [circadian sleep/wake cycle, REM sleep]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043067 [regulation of programmed cell death]
GO:0043206 [extracellular fibril organization]
GO:0043292 [contractile fiber]
GO:0044267 [cellular protein metabolic process]
GO:0045740 [positive regulation of DNA replication]
GO:0045861 [negative regulation of proteolysis]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048678 [response to axon injury]
GO:0060009 [Sertoli cell development]
GO:0060311 [negative regulation of elastin catabolic process]
GO:0060313 [negative regulation of blood vessel remodeling]
GO:0060548 [negative regulation of cell death]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
Show all
 146 aa
15.8 kDa 		Yes 0
CST3-003
ENSP00000381446
ENST00000398409
P01034 [Direct mapping]
Cystatin-C
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001540 [beta-amyloid binding]
GO:0002020 [protease binding]
GO:0004866 [endopeptidase inhibitor activity]
GO:0004869 [cysteine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006952 [defense response]
GO:0010466 [negative regulation of peptidase activity]
GO:0010711 [negative regulation of collagen catabolic process]
GO:0010716 [negative regulation of extracellular matrix disassembly]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0034103 [regulation of tissue remodeling]
GO:0042802 [identical protein binding]
GO:0043206 [extracellular fibril organization]
GO:0044267 [cellular protein metabolic process]
GO:0045861 [negative regulation of proteolysis]
GO:0060311 [negative regulation of elastin catabolic process]
GO:0060313 [negative regulation of blood vessel remodeling]
GO:0070062 [extracellular exosome]
Show all
 146 aa
15.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.