Expression of SPINT3 in cancer - Summary

CANCER ATLAS

Gene description

Serine peptidase inhibitor, Kunitz type, 3

Protein class

Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA057848

Staining summary	A few hepatocellular carcinomas and a fraction of tumor cells in a rare case of lung adenocarcinoma showed moderate cytoplasmic positivity. Remaining cancer tissues were negative.

GENE INFORMATION
Gene name	SPINT3 (HGNC Symbol)
Synonyms	HKIB9
Description	Serine peptidase inhibitor, Kunitz type, 3 (HGNC Symbol)
Entrez gene summary
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	45512461 - 45515624
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101446 (version 83.38)
Entrez gene	10816
UniProt	P49223 (UniProt - Inferred from homology)
neXtProt	NX_P49223
Antibodypedia	SPINT3 antibodies

PROTEIN BROWSER

SPINT3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPINT3-001 ENSP00000217428 ENST00000217428	P49223 [Direct mapping] Kunitz-type protease inhibitor 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] Show all	89 aa 10.3 kDa	Yes	0