Cell atlas - EPPIN - The Human Protein Atlas

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EPPIN

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	EPPIN
Gene description	Epididymal peptidase inhibitor
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	EPPIN (HGNC Symbol)
Synonyms	CT71, dJ461P17.2, EPPIN1, EPPIN2, EPPIN3, SPINLW1, WAP7, WFDC7
Description	Epididymal peptidase inhibitor (HGNC Symbol)
Entrez gene summary	This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	45540626 - 45547752
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101448 (version 83.38)
Entrez gene	57119
UniProt	O95925 (UniProt - Evidence at protein level)
neXtProt	NX_O95925
Antibodypedia	EPPIN antibodies

PROTEIN BROWSER

EPPIN-001	EPPIN-002	EPPIN-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPPIN-001 ENSP00000361746 ENST00000354280	O95925 [Direct mapping] Eppin Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0009986 [cell surface] GO:0010466 [negative regulation of peptidase activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0030414 [peptidase inhibitor activity] GO:0042742 [defense response to bacterium] GO:0043234 [protein complex] GO:0051259 [protein oligomerization] GO:0090281 [negative regulation of calcium ion import] GO:1901318 [negative regulation of sperm motility] Show all	133 aa 15.3 kDa	Yes	0
EPPIN-002 ENSP00000338114 ENST00000336443	O95925 [Direct mapping] Eppin Show all	Predicted intracellular proteins Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0009986 [cell surface] GO:0010466 [negative regulation of peptidase activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0030414 [peptidase inhibitor activity] GO:0042742 [defense response to bacterium] GO:0043234 [protein complex] GO:0051259 [protein oligomerization] GO:0090281 [negative regulation of calcium ion import] GO:1901318 [negative regulation of sperm motility] Show all	117 aa 13.5 kDa	No	0
EPPIN-005 ENSP00000387153 ENST00000409554	B7ZBA9 [Direct mapping] Eppin Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0010466 [negative regulation of peptidase activity] GO:0030414 [peptidase inhibitor activity] Show all	77 aa 8.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.