Cell atlas - DHX35 - The Human Protein Atlas

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DHX35

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nuclear bodies
	Nucleus

Human cell
	Centrosome
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DHX35
Gene description	DEAH (Asp-Glu-Ala-His) box polypeptide 35
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies. In addition localized to the nucleus & centrosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)
Additional location	In addition localized to the Nucleus (approved), Centrosome (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA062700
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies. In addition localized to the nucleus & centrosome.

Main location

Nuclear bodies (approved)

Additional location

Nucleus (approved), Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA062700	CACO-2	Nuclear bodies
	HPA062700	RH-30	Nucleus
			Nuclear bodies
			Centrosome
	HPA062700	U-2 OS	Nuclear bodies

GENE INFORMATION
Gene name	DHX35 (HGNC Symbol)
Synonyms	C20orf15, DDX35, FLJ22759, KAIA0875
Description	DEAH (Asp-Glu-Ala-His) box polypeptide 35 (HGNC Symbol)
Entrez gene summary	DEAD box proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The function of this gene product which is a member of this family, has not been determined. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2010]
Chromosome	20
Cytoband
Chromosome location (bp)	38962299 - 39039723
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101452 (version 83.38)
Entrez gene	60625
UniProt	Q9H5Z1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H5Z1
Antibodypedia	DHX35 antibodies

PROTEIN BROWSER

DHX35-001	DHX35-002	DHX35-006	DHX35-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHX35-001 ENSP00000252011 ENST00000252011	Q9H5Z1 [Direct mapping] Probable ATP-dependent RNA helicase DHX35 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0008026 [ATP-dependent helicase activity] GO:0044822 [poly(A) RNA binding] GO:0071013 [catalytic step 2 spliceosome] Show all	703 aa 78.9 kDa	No	0
DHX35-002 ENSP00000362422 ENST00000373325	Q5THR1 [Direct mapping] Probable ATP-dependent RNA helicase DHX35 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0008026 [ATP-dependent helicase activity] GO:0044822 [poly(A) RNA binding] Show all	679 aa 76 kDa	No	0
DHX35-006 ENSP00000397997 ENST00000449559	Q5THQ7 [Direct mapping] Probable ATP-dependent RNA helicase DHX35 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004004 [ATP-dependent RNA helicase activity] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0044822 [poly(A) RNA binding] Show all	167 aa 19.3 kDa	No	0
DHX35-008 ENSP00000362420 ENST00000373323	Q9H5Z1 [Direct mapping] Probable ATP-dependent RNA helicase DHX35 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0004386 [helicase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006396 [RNA processing] GO:0008026 [ATP-dependent helicase activity] GO:0044822 [poly(A) RNA binding] GO:0071013 [catalytic step 2 spliceosome] Show all	672 aa 75.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.