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TNNC2

GENERAL INFORMATION

Gene name

 TNNC2

Gene description

 Troponin C type 2 (fast)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (skeletal muscle)
GTEx:Tissue enriched (skeletal muscle)
FANTOM5:Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in a subset of skeletal myocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA043174 , HPA058481
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION

Gene name

 TNNC2

Synonyms

Description

 Troponin C type 2 (fast) (HGNC Symbol)

Entrez gene summary

 Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q13.12

Chromosome location (bp)

 45823214 - 45833745

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101470 (version 83.38)

Entrez gene

 7125

UniProt

 P02585 (UniProt - Evidence at protein level)

neXtProt

 NX_P02585

Antibodypedia

 TNNC2 antibodies

PROTEIN BROWSER
TNNC2-001
TNNC2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNNC2-001
ENSP00000361638
ENST00000372557
C9J7T9 [Direct mapping]
Troponin C type 2 (Fast), isoform CRA_a; Troponin C, skeletal muscle
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 145 aa
16.4 kDa 		No 0
TNNC2-003
ENSP00000361636
ENST00000372555
P02585 [Direct mapping]
Troponin C, skeletal muscle
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003009 [skeletal muscle contraction]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0006937 [regulation of muscle contraction]
GO:0030049 [muscle filament sliding]
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 160 aa
18.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.