Tissue expression of CELF4 - Summary - The Human Protein Atlas

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CELF4

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CELF4
Gene description	CUGBP, Elav-like family member 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	18
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (cerebellum, cerebral cortex, hypothalamus, hippocampus, caudate, pituitary gland)
FANTOM5:	Group enriched (cerebellum, hippocampus, caudate, pituitary gland, brain)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in neuronal cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA037986
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, cerebral cortex, hypothalamus, hippocampus, caudate, pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebellum, hippocampus, caudate, pituitary gland, brain)

GENE INFORMATION
Gene name	CELF4 (HGNC Symbol)
Synonyms	BRUNOL4
Description	CUGBP, Elav-like family member 4 (HGNC Symbol)
Entrez gene summary	Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	18
Cytoband	q12.2
Chromosome location (bp)	37243047 - 37566037
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101489 (version 83.38)
Entrez gene	56853
UniProt	Q9BZC1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZC1
Antibodypedia	CELF4 antibodies

PROTEIN BROWSER

CELF4-001	CELF4-002	CELF4-003	CELF4-004	CELF4-007	CELF4-008	CELF4-009	CELF4-011	CELF4-013	CELF4-014	CELF4-015	CELF4-016	CELF4-017	CELF4-020	CELF4-021	CELF4-022	CELF4-023	CELF4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CELF4-001 ENSP00000464917 ENST00000591287	Q9BZC1 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0000380 [alternative mRNA splicing, via spliceosome] GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] GO:0000900 [translation repressor activity, nucleic acid binding] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007281 [germ cell development] GO:0009790 [embryo development] GO:0017148 [negative regulation of translation] GO:0042835 [BRE binding] GO:0048026 [positive regulation of mRNA splicing, via spliceosome] Show all	484 aa 51.8 kDa	No	0
CELF4-002 ENSP00000335631 ENST00000334919	Q9BZC1 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000380 [alternative mRNA splicing, via spliceosome] GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] GO:0000900 [translation repressor activity, nucleic acid binding] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007281 [germ cell development] GO:0009790 [embryo development] GO:0017148 [negative regulation of translation] GO:0042835 [BRE binding] GO:0048026 [positive regulation of mRNA splicing, via spliceosome] Show all	448 aa 47.7 kDa	No	0
CELF4-003 ENSP00000468109 ENST00000588597	B4DHA8 [Direct mapping] CUGBP Elav-like family member 4; cDNA FLJ54925, highly similar to Mus musculus bruno-like 4, RNA binding protein (Drosophila) (Brunol4), mRNA Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	454 aa 48.4 kDa	No	0
CELF4-004 ENSP00000464794 ENST00000591282	Q9BZC1 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0000380 [alternative mRNA splicing, via spliceosome] GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] GO:0000900 [translation repressor activity, nucleic acid binding] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007281 [germ cell development] GO:0009790 [embryo development] GO:0017148 [negative regulation of translation] GO:0042835 [BRE binding] GO:0048026 [positive regulation of mRNA splicing, via spliceosome] Show all	486 aa 52 kDa	No	0
CELF4-007 ENSP00000467571 ENST00000587924	K7EPX2 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	67 aa 7.5 kDa	No	0
CELF4-008 ENSP00000467732 ENST00000587819	K7EQ97 [Direct mapping] CUGBP Elav-like family member 4 Show all	TMHMM predicted membrane proteins Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	154 aa 16.8 kDa	No	0
CELF4-009 ENSP00000465211 ENST00000589229	K7EJK3 [Direct mapping] CUGBP Elav-like family member 4 Show all	TMHMM predicted membrane proteins Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	162 aa 17.6 kDa	No	0
CELF4-011 ENSP00000465125 ENST00000589386	K7EJD7 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	181 aa 19 kDa	No	0
CELF4-013 ENSP00000468256 ENST00000588591	K7ERH1 [Direct mapping] CUGBP Elav-like family member 4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	151 aa 15.6 kDa	No	0
CELF4-014 ENSP00000464996 ENST00000593271	K7EJ26 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	138 aa 14.3 kDa	No	0
CELF4-015 ENSP00000467056 ENST00000587657	K7ENR2 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] Show all	133 aa 13.8 kDa	No	0
CELF4-016 ENSP00000465348 ENST00000586009	K7EJW4 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	115 aa 11.8 kDa	No	0
CELF4-017 ENSP00000471616 ENST00000587911	M0R137 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	69 aa 7.6 kDa	No	0
CELF4-020 ENSP00000470649 ENST00000601392	A0A0C4DGR1 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	294 aa 31.9 kDa	No	0
CELF4-021 ENSP00000469627 ENST00000601019	M0QY66 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	484 aa 51.8 kDa	No	0
CELF4-022 ENSP00000474788 ENST00000603232	S4R3V5 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	485 aa 51.9 kDa	No	0
CELF4-023 ENSP00000355089 ENST00000361795	Q9BZC1 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000380 [alternative mRNA splicing, via spliceosome] GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] GO:0000900 [translation repressor activity, nucleic acid binding] GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007281 [germ cell development] GO:0009790 [embryo development] GO:0017148 [negative regulation of translation] GO:0042835 [BRE binding] GO:0048026 [positive regulation of mRNA splicing, via spliceosome] Show all	484 aa 51.7 kDa	No	0
CELF4-201 ENSP00000410584 ENST00000420428	Q9BZC1 [Direct mapping] CUGBP Elav-like family member 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0000380 [alternative mRNA splicing, via spliceosome] GO:0000381 [regulation of alternative mRNA splicing, via spliceosome] GO:0000900 [translation repressor activity, nucleic acid binding] GO:0003676 [nucleic acid binding] GO:0003729 [mRNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006376 [mRNA splice site selection] GO:0007281 [germ cell development] GO:0009790 [embryo development] GO:0017148 [negative regulation of translation] GO:0042835 [BRE binding] GO:0048025 [negative regulation of mRNA splicing, via spliceosome] GO:0048026 [positive regulation of mRNA splicing, via spliceosome] GO:0090394 [negative regulation of excitatory postsynaptic potential] Show all	486 aa 52 kDa	No	0

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The Human Protein Atlas

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