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Cancer cells displayed weak to moderate granular cytoplasmic staining. Most head & neck cancers, cervical cancers, gliomas and testis cancers were negative.
GENE INFORMATION
Gene name
ZNF516 (HGNC Symbol)
Synonyms
HsT287, KIAA0222
Description
Zinc finger protein 516 (HGNC Symbol)
Entrez gene summary
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]
Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0009409 [response to cold] GO:0033613 [activating transcription factor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:0050873 [brown fat cell differentiation] GO:0060612 [adipose tissue development]
