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USP14

GENERAL INFORMATION

Gene name

 USP14

Gene description

 Ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA001308
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 USP14 (HGNC Symbol)

Synonyms

 TGT

Description

 Ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 p11.32

Chromosome location (bp)

 158383 - 214629

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101557 (version 83.38)

Entrez gene

 9097

UniProt

 P54578 (UniProt - Evidence at protein level)

neXtProt

 NX_P54578

Antibodypedia

 USP14 antibodies

PROTEIN BROWSER
USP14-001
USP14-002
USP14-003
USP14-004
USP14-006
USP14-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP14-001
ENSP00000464447
ENST00000582707
P54578 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 14
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0004866 [endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008193 [tRNA guanylyltransferase activity]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0050920 [regulation of chemotaxis]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0070628 [proteasome binding]
GO:1903070 [negative regulation of ER-associated ubiquitin-dependent protein catabolic process]
Show all
 459 aa
52.4 kDa 		No 0
USP14-002
ENSP00000383125
ENST00000400266
P54578 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 14
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0004866 [endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008193 [tRNA guanylyltransferase activity]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0050920 [regulation of chemotaxis]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0070628 [proteasome binding]
GO:1903070 [negative regulation of ER-associated ubiquitin-dependent protein catabolic process]
Show all
 483 aa
54.8 kDa 		No 0
USP14-003
ENSP00000261601
ENST00000261601
P54578 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 14
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0004866 [endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007268 [synaptic transmission]
GO:0008193 [tRNA guanylyltransferase activity]
GO:0009986 [cell surface]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045202 [synapse]
GO:0050920 [regulation of chemotaxis]
GO:0061136 [regulation of proteasomal protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0070628 [proteasome binding]
GO:1903070 [negative regulation of ER-associated ubiquitin-dependent protein catabolic process]
Show all
 494 aa
56.1 kDa 		No 0
USP14-004
ENSP00000373083
ENST00000383589
A6NJA2 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0016579 [protein deubiquitination]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
Show all
 448 aa
51.1 kDa 		No 0
USP14-006
ENSP00000463891
ENST00000580410
J3QQT6 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 14
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
Show all
 20 aa
2.2 kDa 		No 0
USP14-007
ENSP00000462315
ENST00000581983
J3KS55 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 14
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
Show all
 28 aa
3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.