Cell atlas - MYL12A - The Human Protein Atlas

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MYL12A

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MYL12A
Gene description	Myosin, light chain 12A, regulatory, non-sarcomeric
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nucleoli (fibrillar center). Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nucleoli fibrillar center (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA045244
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nucleoli (fibrillar center). Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Nucleus (approved), Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA045244	BJ	Nucleus
	HPA045244	BJ	Nucleoli fibrillar center
	HPA045244	CACO-2	Nucleoli fibrillar center
	HPA045244	U-2 OS	Nucleus
	HPA045244	U-2 OS	Nucleoli fibrillar center

GENE INFORMATION
Gene name	MYL12A (HGNC Symbol)
Synonyms	MLCB, MRCL3, MRLC3, MYL2B
Description	Myosin, light chain 12A, regulatory, non-sarcomeric (HGNC Symbol)
Entrez gene summary	This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]
Chromosome	18
Cytoband	p11.31
Chromosome location (bp)	3247481 - 3256236
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000101608 (version 83.38)
Entrez gene	10627
UniProt	P19105 (UniProt - Evidence at protein level)
neXtProt	NX_P19105
Antibodypedia	MYL12A antibodies

PROTEIN BROWSER

MYL12A-001	MYL12A-002	MYL12A-003	MYL12A-004	MYL12A-005	MYL12A-008	MYL12A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYL12A-001 ENSP00000217652 ENST00000217652	P19105 [Direct mapping] Myosin regulatory light chain 12A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006936 [muscle contraction] GO:0007411 [axon guidance] GO:0016459 [myosin complex] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070527 [platelet aggregation] Show all	171 aa 19.8 kDa	No	0
MYL12A-002 ENSP00000462171 ENST00000579226	P19105 [Direct mapping] Myosin regulatory light chain 12A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006936 [muscle contraction] GO:0007411 [axon guidance] GO:0016459 [myosin complex] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070527 [platelet aggregation] Show all	171 aa 19.8 kDa	No	0
MYL12A-003 ENSP00000462865 ENST00000583449	J3KT92 [Direct mapping] Myosin regulatory light chain 12A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		12 aa 1.4 kDa	No	0
MYL12A-004 ENSP00000463614 ENST00000578611	P19105 [Direct mapping] Myosin regulatory light chain 12A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006936 [muscle contraction] GO:0007411 [axon guidance] GO:0016459 [myosin complex] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070527 [platelet aggregation] Show all	171 aa 19.8 kDa	No	0
MYL12A-005 ENSP00000464359 ENST00000580887	J3QRS3 [Direct mapping] Myosin regulatory light chain 12A; Myosin regulatory light chain MRCL3, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001725 [stress fiber] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0008360 [regulation of cell shape] GO:0016460 [myosin II complex] GO:0030018 [Z disc] GO:0035254 [glutamate receptor binding] GO:0043234 [protein complex] GO:0072661 [protein targeting to plasma membrane] Show all	177 aa 20.5 kDa	No	0
MYL12A-008 ENSP00000463009 ENST00000578562	J3KTJ1 [Direct mapping] Myosin regulatory light chain 12A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	114 aa 13.1 kDa	No	0
MYL12A-201 ENSP00000441231 ENST00000536605	P19105 [Direct mapping] Myosin regulatory light chain 12A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006936 [muscle contraction] GO:0007411 [axon guidance] GO:0016459 [myosin complex] GO:0048013 [ephrin receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0070527 [platelet aggregation] Show all	171 aa 19.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.