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ST8SIA5

GENERAL INFORMATION

Gene name

 ST8SIA5

Gene description

 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, adrenal gland)
GTEx:Tissue enhanced (cerebellum, adrenal gland)
FANTOM5:Tissue enriched (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in CNS and adrenal gland.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA043813 , HPA046771
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum, adrenal gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebellum)

GENE INFORMATION

Gene name

 ST8SIA5 (HGNC Symbol)

Synonyms

 SIAT8E

Description

 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a type II membrane protein that may be present in the Golgi apparatus. The encoded protein, which is a member of glycosyltransferase family 29, may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b, and GT3 from GD1a, GT1b, GM1b, and GD3, respectively. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 q21.1

Chromosome location (bp)

 46667821 - 46759257

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101638 (version 83.38)

Entrez gene

 29906

UniProt

 O15466 (UniProt - Evidence at protein level)

neXtProt

 NX_O15466

Antibodypedia

 ST8SIA5 antibodies

PROTEIN BROWSER
ST8SIA5-001
ST8SIA5-002
ST8SIA5-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ST8SIA5-001
ENSP00000321343
ENST00000315087
O15466 [Direct mapping]
Alpha-2,8-sialyltransferase 8E
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0005515 [protein binding]
GO:0005975 [carbohydrate metabolic process]
GO:0006486 [protein glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006688 [glycosphingolipid biosynthetic process]
GO:0008373 [sialyltransferase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030173 [integral component of Golgi membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0097503 [sialylation]
Show all
 376 aa
43.9 kDa 		No 2
ST8SIA5-002
ENSP00000443683
ENST00000536490
F5H8D1 [Direct mapping]
Alpha-2,8-sialyltransferase 8E
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0006486 [protein glycosylation]
GO:0008373 [sialyltransferase activity]
GO:0030173 [integral component of Golgi membrane]
GO:0097503 [sialylation]
Show all
 345 aa
40.1 kDa 		No 2
ST8SIA5-004
ENSP00000445492
ENST00000538168
O15466 [Direct mapping]
Alpha-2,8-sialyltransferase 8E
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0000139 [Golgi membrane]
GO:0003828 [alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity]
GO:0005515 [protein binding]
GO:0005975 [carbohydrate metabolic process]
GO:0006486 [protein glycosylation]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0006688 [glycosphingolipid biosynthetic process]
GO:0008373 [sialyltransferase activity]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030173 [integral component of Golgi membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0097503 [sialylation]
Show all
 412 aa
47.7 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.