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SMAD7

CANCER ATLAS

Gene description

 SMAD family member 7

Protein class

 Disease related genes, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028897
CAB026212

GENE INFORMATION

Gene name

 SMAD7 (HGNC Symbol)

Synonyms

 MADH7, MADH8

Description

 SMAD family member 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

 18

Cytoband

 q21.1

Chromosome location (bp)

 48919853 - 48950711

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101665 (version 83.38)

Entrez gene

 4092

UniProt

 O15105 (UniProt - Evidence at protein level)

neXtProt

 NX_O15105

Antibodypedia

 SMAD7 antibodies

PROTEIN BROWSER
SMAD7-001
SMAD7-002
SMAD7-005
SMAD7-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMAD7-001
ENSP00000262158
ENST00000262158
O15105 [Direct mapping]
Mothers against decapentaplegic homolog 7
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001657 [ureteric bud development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008013 [beta-catenin binding]
GO:0010467 [gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016342 [catenin complex]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030336 [negative regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030617 [transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032925 [regulation of activin receptor signaling pathway]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034333 [adherens junction assembly]
GO:0034616 [response to laminar fluid shear stress]
GO:0034629 [cellular protein complex localization]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048185 [activin binding]
GO:0048844 [artery morphogenesis]
GO:0050821 [protein stabilization]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060373 [regulation of ventricular cardiac muscle cell membrane depolarization]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060394 [negative regulation of pathway-restricted SMAD protein phosphorylation]
GO:0060412 [ventricular septum morphogenesis]
GO:0070411 [I-SMAD binding]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
Show all
 426 aa
46.4 kDa 		No 0
SMAD7-002
ENSP00000466902
ENST00000591805
O15105 [Direct mapping]
Mothers against decapentaplegic homolog 7
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008013 [beta-catenin binding]
GO:0010467 [gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016342 [catenin complex]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030336 [negative regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030617 [transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032925 [regulation of activin receptor signaling pathway]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034333 [adherens junction assembly]
GO:0034616 [response to laminar fluid shear stress]
GO:0034629 [cellular protein complex localization]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048185 [activin binding]
GO:0048844 [artery morphogenesis]
GO:0050821 [protein stabilization]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060373 [regulation of ventricular cardiac muscle cell membrane depolarization]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060394 [negative regulation of pathway-restricted SMAD protein phosphorylation]
GO:0060412 [ventricular septum morphogenesis]
GO:0070411 [I-SMAD binding]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
Show all
 211 aa
23.9 kDa 		No 0
SMAD7-005
ENSP00000467621
ENST00000589634
O15105 [Direct mapping]
Mothers against decapentaplegic homolog 7
Show all
Predicted intracellular proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Disease related genes
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005913 [cell-cell adherens junction]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0008013 [beta-catenin binding]
GO:0010467 [gene expression]
GO:0010719 [negative regulation of epithelial to mesenchymal transition]
GO:0010801 [negative regulation of peptidyl-threonine phosphorylation]
GO:0010944 [negative regulation of transcription by competitive promoter binding]
GO:0016342 [catenin complex]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030336 [negative regulation of cell migration]
GO:0030509 [BMP signaling pathway]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030617 [transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity]
GO:0031397 [negative regulation of protein ubiquitination]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032925 [regulation of activin receptor signaling pathway]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034333 [adherens junction assembly]
GO:0034616 [response to laminar fluid shear stress]
GO:0034629 [cellular protein complex localization]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048185 [activin binding]
GO:0048844 [artery morphogenesis]
GO:0050821 [protein stabilization]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0055117 [regulation of cardiac muscle contraction]
GO:0060373 [regulation of ventricular cardiac muscle cell membrane depolarization]
GO:0060389 [pathway-restricted SMAD protein phosphorylation]
GO:0060394 [negative regulation of pathway-restricted SMAD protein phosphorylation]
GO:0060412 [ventricular septum morphogenesis]
GO:0070411 [I-SMAD binding]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
Show all
 425 aa
46.4 kDa 		No 0
SMAD7-007
ENSP00000465590
ENST00000586093
K7EKF0 [Direct mapping]
Mothers against decapentaplegic homolog 7
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 158 aa
17.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.