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LIPG

GENERAL INFORMATION

Gene name

 LIPG

Gene description

 Lipase, endothelial

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (thyroid gland, placenta)
GTEx:Tissue enriched (thyroid gland)
FANTOM5:Tissue enhanced (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression

 Extracellular deposits and cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability score

 Uncertain based on 1 antibody.
HPA016966
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (thyroid gland, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (thyroid gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland)

GENE INFORMATION

Gene name

 LIPG (HGNC Symbol)

Synonyms

 EDL

Description

 Lipase, endothelial (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008]

Chromosome

 18

Cytoband

 q21.1

Chromosome location (bp)

 49560699 - 49599182

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000101670 (version 83.38)

Entrez gene

 9388

UniProt

 Q9Y5X9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5X9

Antibodypedia

 LIPG antibodies

PROTEIN BROWSER
LIPG-001
LIPG-002
LIPG-003
LIPG-004
LIPG-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIPG-001
ENSP00000261292
ENST00000261292
Q9Y5X9 [Direct mapping]
Endothelial lipase
A0A024R2B5 [Target identity:100%; Query identity:100%]
Lipase, endothelial, isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004465 [lipoprotein lipase activity]
GO:0004620 [phospholipase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0006629 [lipid metabolic process]
GO:0007584 [response to nutrient]
GO:0008201 [heparin binding]
GO:0008283 [cell proliferation]
GO:0008970 [phosphatidylcholine 1-acylhydrolase activity]
GO:0009395 [phospholipid catabolic process]
GO:0009986 [cell surface]
GO:0010983 [positive regulation of high-density lipoprotein particle clearance]
GO:0032376 [positive regulation of cholesterol transport]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0042632 [cholesterol homeostasis]
GO:0043691 [reverse cholesterol transport]
GO:0050746 [regulation of lipoprotein metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0055091 [phospholipid homeostasis]
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 500 aa
56.8 kDa 		Yes 0
LIPG-002
ENSP00000387978
ENST00000427224
B4DTR8 [Direct mapping]
Endothelial lipase; cDNA FLJ57818, highly similar to Endothelial lipase (EC 3.1.1.3)
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004465 [lipoprotein lipase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006629 [lipid metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
Show all
 426 aa
49 kDa 		Yes 0
LIPG-003
ENSP00000462420
ENST00000580036
Q9Y5X9 [Direct mapping]
Endothelial lipase
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004465 [lipoprotein lipase activity]
GO:0004620 [phospholipase activity]
GO:0005615 [extracellular space]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0006629 [lipid metabolic process]
GO:0008201 [heparin binding]
GO:0008970 [phosphatidylcholine 1-acylhydrolase activity]
GO:0009395 [phospholipid catabolic process]
GO:0009986 [cell surface]
GO:0010983 [positive regulation of high-density lipoprotein particle clearance]
GO:0032376 [positive regulation of cholesterol transport]
GO:0034375 [high-density lipoprotein particle remodeling]
GO:0042632 [cholesterol homeostasis]
GO:0043691 [reverse cholesterol transport]
GO:0055091 [phospholipid homeostasis]
Show all
 354 aa
39.4 kDa 		Yes 0
LIPG-004
ENSP00000463835
ENST00000577628
J3QQQ0 [Direct mapping]
Endothelial lipase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004465 [lipoprotein lipase activity]
GO:0005576 [extracellular region]
GO:0006629 [lipid metabolic process]
Show all
 390 aa
43.2 kDa 		No 0
LIPG-006
ENSP00000463077
ENST00000583083
J3KTN7 [Direct mapping]
Endothelial lipase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
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 24 aa
2.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.