We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Cancer tissues showed moderate to strong cytoplasmic positivity with additional membranous staining in several cases. Several cases of gliomas, lymphomas and renal cancers were weakly stained or negative.
Moderate cytoplasmic positivity was observed in breast and pancreatic cancers along with several colorectal, prostate, ovarian and urothelial cancers. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
LAMA1 (HGNC Symbol)
Synonyms
LAMA
Description
Laminin, alpha 1 (HGNC Symbol)
Entrez gene summary
This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)